KCTD11

potassium channel tetramerization domain containing 11

Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

KCTD11 (4)

Publications

No (4)

Tag

His (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Purification

Purified (1)

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Human KCTD11 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72570

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.7 kDa

Price:

20 µg/$1,107

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Human KCTD11 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92901

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.7 kDa

Price:

20 µg/$150

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KCTD11 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122590

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.7 kDa

Price:

100 µg/$494

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Human KCTD11 Protein (Recombinant His) - LS-G2197

Source:

E. coli

Tag:

His

Price:

50 µg/$392; 250 µg/$872; 10 µg/$286; 20 µg/$348; 100 µg/$511; 500 µg/$1,355

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