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KCNU1 / KCNMC1
potassium channel, subfamily U, member 1
Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K+. May represent the primary spermatozoan K+ current. In contrast to KCNMA1/SLO1, it is not activated by Ca2+ or Mg2+. Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.
| Gene Name: | potassium channel, subfamily U, member 1 |
| Synonyms: | KCNU1, KCa5, KCNMC1, Kcnma3, KCa5.1, Kcnu1, Slo3, Slowpoke homolog 3 |
| Target Sequences: | NM_001031836 NP_001027006.2 A8MYU2 |
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