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KCNN3 / SK3

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Family/Subfamily: Ion Channel , Potassium channel - calcium-activated
Synonyms: KCNN3, KCa2.3, HSK3, SKCa 3, SKCA3, K3, SK3
Target Sequences: NM_002249 NP_002240.3 Q9UGI6

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Products
Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
KCNN3 / SK3 (7)
No (7)
GST (2)
GST, N-terminus (1)
Myc-DDK (Flag) (4)
Human (5)
293T Cells (2)
HEK 293 Cells (2)
Wheat Germ Extract (3)
Purified (2)
KCNN3 / SK3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
47.9 kDa
20 µg/$150
KCNN3 / SK3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
81.2 kDa
20 µg/$215
KCNN3 / SK3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
2 µg/$439
KCNN3 / SK3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
47.9 kDa
100 µg/$494
KCNN3 / SK3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
81.2 kDa
100 µg/$710
KCNN3 / SK3 Protein - 12.5% SDS-PAGE of human KCNN3 stained with Coomassie Blue
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Wheat Germ Extract
GST
72.6 kDa
2 µg/$439
KCNN3 / SK3 Protein - 12.5% SDS-PAGE of human KCNN3 stained with Coomassie Blue
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Wheat Germ Extract
GST
74.5 kDa
10 µg/$479; 25 µg/$670
Viewing 1-7 of 7 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).