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KCNK10 / TREK belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Gene Name: | potassium channel, subfamily K, member 10 |
Family/Subfamily: | Ion Channel , Potassium channel - two pore |
Synonyms: | KCNK10, K2p10.1, TREK-2, TREK2, TWIK-related K+ channel 2, TREK-2 K(+) channel subunit, Potassium channel TREK-2 |
Target Sequences: | NM_021161 NP_066984.1 P57789 |
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