KCNJ3 / GIRK1

potassium inwardly-rectifying channel, subfamily J, member 3

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins.

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Proteins (2)

Type

Over-Expression Lysate (2)

Target

KCNJ3 / GIRK1 (2)

Publications

No (2)

Tag

Myc-DDK (Flag) (2)

Species

Human (1)

Source

293T Cells (1)

HEK 293 Cells (1)

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KCNJ3 / GIRK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99695

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.4 kDa

Price:

100 µg/$494

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Human KCNJ3 / GIRK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75999

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.4 kDa

Price:

20 µg/$150

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