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KCNJ3 / GIRK1
potassium inwardly-rectifying channel, subfamily J, member 3
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins.
| Gene Name: | potassium inwardly-rectifying channel, subfamily J, member 3 |
| Family/Subfamily: | Ion Channel , Potassium channel - inward-rectifying |
| Synonyms: | KCNJ3, GIRK1, Kcnf3, KIR3.1, GIRK-1, HGIRK1, KGA |
| Target Sequences: | NM_002239 NP_002230.1 |
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