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KCNH2 / HERG
potassium voltage-gated channel, subfamily H (eag-related), member 2
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.
| Gene Name: | potassium voltage-gated channel, subfamily H (eag-related), member 2 |
| Family/Subfamily: | Ion Channel , Potassium channel - Eag-related |
| Synonyms: | KCNH2, Eag homolog, HERG-1, ERG1, HERG, KV11.1, M-erg1, H-ERG, HERG1, SQT1, LQT2, Merg1, Eag-related protein 1, ERG-1 |
| Target Sequences: | NM_000238 NP_000229.1 Q12809 |
Publications (2)
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