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KCNA1 / Kv1.1

potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)

KCNA1 / Kv1.1 is a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).

Gene Name: potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
Family/Subfamily: Ion Channel , Potassium channel - Kv1 Shaker
Synonyms: KCNA1, EA1, AEMK, HBK1, KV1.1, HUK1, RCK1, MK1, RBK1, MBK1
Target Sequences: NM_000217 NP_000208.2 Q09470

☰ Filters
Antibodies (37)
Proteins (5)
Over-Expression Lysate (2)
Primary (37)
Recombinant (3)
KCNA1 / Kv1.1 (42)
Human (36)
Mouse (15)
Rat (14)
Bat (3)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Horse (3)
Monkey (3)
Pig (4)
IHC (12)
IHC-P (3)
WB (33)
ELISA (21)
ICC (1)
IF (2)
IP (1)
Peptide-ELISA (2)
rabbit (35)
mouse (2)
Product Group
PathPlus Neuro (2)
IgG (26)
IgG2a,k (1)
monoclonal mc (1)
polyclonal pc (36)
2D8 (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (1)
Unconjugated (23)
aa172-201 (7)
aa179-228 (4)
230-310 aa, Internal (1)
C-Terminus (1)
Internal (1)
aa239-288 (1)
aa256-305 (1)
aa298-343 (1)
aa465-481 (1)
No (42)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (2)
KCNA1 / Kv1.1 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal (aa239-288) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
KCNA1 / Kv1.1 Antibody - Detection limit for recombinant GST tagged KCNA1 is 0.3 ng/ml as a capture antibody.
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KCNA1 / Kv1.1 Mouse anti-Human Monoclonal (2D8) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
Select
E. coli
6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
KCNA1 / Kv1.1 Protein - 12.5% SDS-PAGE of human KCNA1 stained with Coomassie Blue
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Wheat Germ Extract
GST
82.9 kDa
10 µg/$479; 25 µg/$670
KCNA1 / Kv1.1 Antibody - Anti-KCNA1 / Kv1.1 antibody IHC of human brain, cerebellum, Purkinje cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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Neuroscience
KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal (aa256-305) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
KCNA1 / Kv1.1 Antibody - KCNA1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human cerebellum tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal (aa172-201) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, WB
Unconjugated
200 µl/$468
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
KCNA1 / Kv1.1 Antibody - WB of KCNA1 / Kv1.1 antibody. All lanes: Anti-KCNA1 at 0.5ug/ml. Lane 1: Rat Brain Tissue Lysate at 40ug. Lane 2: Rat Testis Tissue Lysate at 40ug. Lane 3: Rat Cardiac Muscle Tissue Lysate at 40ug. Lane 4: HELA Whole Cell Lysate at 40ug. Lane 5: U87 Whole Cell Lysate at 40ug. Lane 6: SHG Whole Cell Lysate at 40ug. Lane 7: NEURO Whole Cell Lysate at 40ug. Predicted bind size: 56KD. Observed bind size: 56KD.
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal (aa465-481) Antibody
Mouse, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
KCNA1 / Kv1.1 Antibody - Immunofluorescent analysis of HepG2 cells using KCNA1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal (aa172-201) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal (aa172-201) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal (aa172-201) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal (aa172-201) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal (aa172-201) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal (aa172-201) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
KCNA1 / Kv1.1 Antibody - Immunohistochemistry of paraffin-embedded Human cervical cancer using KCNA1 Polyclonal Antibody at dilution of 1:30.
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal (aa298-343) Antibody
Mouse, Rat, Human
ICC, WB
Unconjugated
50 µl/$321; 100 µl/$403
KCNA1 / Kv1.1 Antibody - Western blot testing of 1) rat brain and 2) mouse brain lysate with KCNA1 antibody at 0.5ug/ml. Expected molecular weight: 56-85 kDa depending on glycosylation level.
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KCNA1 / Kv1.1 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, WB
Unconjugated
100 µg/$575
KCNA1 / Kv1.1 Antibody - Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using KCNA1 antibody.
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
KCNA1 / Kv1.1 Antibody - Western blot analysis of Human kidney cancer tissue, using KCNA1 Polyclonal Antibody at dilution of 1:600.
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
KCNA1 / Kv1.1 Antibody - Western blot analysis of KCNA1 using anti-KCNA1 antibody. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: rat brain tissue lysates,Lane 2: mouse brain tissue lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-KCNA1 antigen affinity purified polyclonal antibody at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1% Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for KCNA1 at approximately 75KD. The expected band size for KCNA1 is at 56KD.
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
KCNA1 / Kv1.1 Antibody - Western blot analysis of extracts from HeLa cells, MCF-7 cells and HuvEc cells, using KCNA1 antibody.
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
KCNA1 / Kv1.1 Antibody - Western blot of KV1.1 antibody
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal (230-310 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
KCNA1 / Kv1.1 Antibody - Western blot analysis of Kv1.1 expression in HEK293 (A); MCF7 (B) whole cell lysates.
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KCNA1 / Kv1.1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Dog, Rat, Pig, Human
IP, WB
Unconjugated
100 µl/$299
Viewing 1-25 of 42 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).