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Duet is a TRIO/TRAD serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains. Duet protein was localized to actin-associated cytoskeletal elements, suggesting a role in the cytoskeleton-dependent cell function. Huntington's disease is an inherited neurodegenerative disease which occurs when the widely expressed protein huntingtin contains an expanded glutamine repeat. HAPIP protein binds to HAP1, which is a huntington binding protein that may function in vesicle trafficking.
Gene Name: | kalirin, RhoGEF kinase |
Family/Subfamily: | Protein Kinase , TRIO/TRAD |
Synonyms: | KALRN, ARHGEF24, DUO, CHDS5, DUET, HAPIP, Kalirin, RhoGEF kinase, Kalirin, Protein Duo, TRAD |
Target Sequences: | NM_001024660 NP_001019831.2 O60229 |
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