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Junctin / ASPH

aspartate beta-hydroxylase

Junctin / ASPH is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.

Gene Name: aspartate beta-hydroxylase
Synonyms: ASPH, A beta H-J-J, AAH, ASP beta-hydroxylase, BAH, Aspartate beta-hydroxylase, CASQ2BP1, Cardiac junctin, HAAH, Humbug, JCTN, Junctate, Junctin
Target Sequences: NM_004318 NP_004309.2 Q12797

Publications (3)

1
Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation. Molina CE, Abu-Taha IH, Wang Q, Roselló-Díez E, Kamler M, Nattel S, Ravens U, Wehrens XHT, Hove-Madsen L, Heijman J, Dobrev D. Frontiers in physiology. 2018 October;9:1383. [Full Text Article] [PubMed:30356673] [PMC:PMC6189336] Related Antibodies: LS-C196703.
2
Modulation of miR-29 influences myocardial compliance likely through coordinated regulation of calcium handling and extracellular matrix. Xiaoming Zhang, Jared M McLendon, Bailey D Peck, Biyi Chen, Long-Sheng Song, Ryan L Boudreau. Molecular therapy. Nucleic acids. 2023 December;34:102081. [Full Text Article] [PubMed:38111915] [PMC:PMC10726423] Related Antibodies: LS-C81640.
3
The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias. Chen W, Wang R, Chen B, Zhong X, Kong H, Bai Y, Zhou Q, Xie C, Zhang J, Guo A, Tian X, Jones PP, O'Mara ML, Liu Y, Mi T, Zhang L, Bolstad J, Semeniuk L, Cheng H, Zhang J, Chen J, Tieleman DP, Gillis AM, Duff HJ, Fill M, Song LS, Chen SR. Nature medicine. Feb;20:184-92. [Full Text Article] [PubMed:24441828] [PMC:PMC4269524] Related Antibodies: LS-C81640.

☰ Filters
Products
Proteins (18)
Over-Expression Lysate (8)
Recombinant (10)
Junctin / ASPH (18)
No (18)
GST (1)
GST, N-terminus (1)
His (1)
His-SUMO (1)
His-T7 (1)
Myc-DDK (Flag) (13)
Human (14)
293T Cells (4)
E. coli (3)
HEK 293 Cells (9)
Wheat Germ Extract (2)
Purified (2)
Junctin / ASPH Protein - Purified recombinant protein ASPH was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
85.7 kDa
20 µg/$1,107
Junctin / ASPH Protein - Purified recombinant protein ASPH was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
32.2 kDa
20 µg/$1,107
Junctin / ASPH Protein - Purified recombinant protein ASPH was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
29.6 kDa
20 µg/$1,107
Junctin / ASPH Protein - Purified recombinant protein ASPH was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
33.6 kDa
20 µg/$1,107
Junctin / ASPH Protein - Purified recombinant protein ASPH was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
34.5 kDa
20 µg/$1,107
Junctin / ASPH Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Junctin / ASPH Protein
Select
E. coli
His-SUMO
38.2 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Junctin / ASPH Protein - Recombinant  Aspartate Beta Hydroxylase By SDS-PAGE
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E. coli
His-T7
26.6 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
Junctin / ASPH Protein - 12.5% SDS-PAGE of human ASPH stained with Coomassie Blue
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Wheat Germ Extract
GST
50.2 kDa
2 µg/$439
Junctin / ASPH Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
31.3 kDa
20 µg/$150
Junctin / ASPH Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
85.7 kDa
20 µg/$215
Junctin / ASPH Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
34.5 kDa
20 µg/$150
Junctin / ASPH Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
33.6 kDa
20 µg/$150
Junctin / ASPH Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
85.7 kDa
100 µg/$710
Junctin / ASPH Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
34.5 kDa
100 µg/$494
Junctin / ASPH Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
33.6 kDa
100 µg/$494
Junctin / ASPH Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
31.3 kDa
100 µg/$494
Junctin / ASPH Protein
Select
E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
Viewing 1-18 of 18 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).