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JUN / c-Jun

jun proto-oncogene

c-Jun is a component of the transcription factor activator protein 1 (AP-1) that binds to and activates transcription at TRE/AP-1 elements. Phosphorylation of c-Jun at Ser 63/73, resulting in activation and c-Jun dependent transcription, occurs in response to extra or intracellular signals, including UV irradiation, growth factors and transforming oncoproteins.

Gene Name: jun proto-oncogene
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: JUN, Activator protein 1, AP-1, C-Jun, Jun proto-oncogene, p39, Jun oncogene, Proto-oncogene c-Jun, AP1, Enhancer-binding protein AP1, G0s7, Transcription factor AP-1, v-jun
Target Sequences: NM_002228 NP_002219.1 P05412

Publications (3)

1
Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos. Liao G, Tao Q, Kofron M, Chen JS, Schloemer A, Davis RJ, Hsieh JC, Wylie C, Heasman J, Kuan CY. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:16313-8. (WB) [PubMed:17060633] [PMC:PMC1637579]
2
Clara cells protein, prolactin and transcription factors of protein NF-?B and c-Jun/AP-1 levels in rats inhaled to stainless steel welding dust and its soluble form. Halatek T, Stanislawska M, Swiercz R, Domeradzka-Gajda K, Kuras R, Wasowicz W. International Journal of Occupational Medicine and Environmental Health. 2018 October;31:613-632. [Full Text Article] [PubMed:30283154]
3
HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy. Michael F Emmons, Fernanda Faião-Flores, Ritin Sharma, Ram Thapa, Jane L Messina, Jurgen C Becker, Dirk Schadendorf, Edward Seto, Vernon K Sondak, John M Koomen, Yian A Chen, Eric K Lau, Lixin Wan, Jonathan D Licht, Keiran S M Smalley. Cancer research. 2019 June;79:2947-2961. [Full Text Article] [PubMed:30987999] [PMC:PMC6548652]

☰ Filters
Products
Proteins (8)
Over-Expression Lysate (3)
Recombinant (5)
JUN / c-Jun (8)
No (8)
6His, N-terminus (1)
8His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (1)
His, N-terminus (1)
Myc-DDK (Flag) (2)
Human (7)
293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
JUN / c-Jun Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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E. coli
6His, N-terminus
37 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949
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HEK 293 Cells
8His, N-terminus
37 kDa
100 µg/$298
JUN / c-Jun Protein - 12.5% SDS-PAGE of human JUN stained with Coomassie Blue
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Wheat Germ Extract
GST
62.1 kDa
2 µg/$439
JUN / c-Jun Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
JUN / c-Jun Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
35.5 kDa
20 µg/$150
JUN / c-Jun Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
35.5 kDa
100 µg/$494
JUN / c-Jun Protein
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E. coli
His
10 µg/$361; 50 µg/$739
JUN / c-Jun Protein - Recombinant V-Jun Sarcoma Virus 17 Oncogene Homolog By SDS-PAGE
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E. coli
His, N-terminus
30.4 kDa
50 µg/$452; 10 µg/$283; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).