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Essential sperm cell-surface protein required for fertilization by acting as a ligand for FOLR4/JUNO receptor on egg. The IZUMO1:FOLR4/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.
Gene Name: | izumo sperm-egg fusion 1 |
Synonyms: | IZUMO1, IZUMO, Oocyte binding/fusion factor, OBF, Sperm-specific protein izumo, Izumo sperm-egg fusion 1 |
Target Sequences: | AA383134 Q8IYV9 Q8IYV9 |
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