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ITPR2 / IP3 Receptor Type 2 belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.
Gene Name: | inositol 1,4,5-trisphosphate receptor, type 2 |
Family/Subfamily: | Ion Channel , Inositol 1,4,5-triphosphate receptor |
Synonyms: | ITPR2, IP3R 2, InsP3R2, IP3R2, InsP3R type II, IP3 receptor, InsP3R type 2, IP3 receptor isoform 2, Type 2 InsP3 receptor |
Target Sequences: | NM_002223 NP_002214.2 Q14571 |
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