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Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Gene Name: | Inosine Triphosphatase (Nucleoside Triphosphate Pyrophosphatase) |
Synonyms: | ITPA, C20orf37, HLC14-06-P, Inosine triphosphatase-A, ITPase, My049, DJ794I6.3, Inosine triphosphatase, NTPase |
Target Sequences: | NM_033453 NP_258412.1 Q9BY32 |
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