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Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
Gene Name: | integral membrane protein 2C |
Synonyms: | ITM2C, BRICHOS domain containing 2C, BRICD2C, Cerebral protein 14, E25C, E25, Integral membrane protein 2C, Integral membrane protein 3, HRPC.1050_D_4, ITM3, Transmembrane protein BRI3 |
Target Sequences: | NM_030926 NP_112188.1 Q9NQX7 |
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