ITGB3 / Integrin Beta 3 / CD61

integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

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Products

Proteins (7)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Recombinant (3)

Target

ITGB3 / Integrin Beta 3 / CD61 (7)

Publications

No (7)

Tag

His, N-Terminal (3)

His-S (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (4)

Purification

Supernatant (1)

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Human ITGB3 / Integrin Beta 3 / CD61 Protein (Recombinant His, N-Terminal) (aa135-377) - LS-G13587

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

32.9 kDa

Price:

10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796

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ITGB3 / Integrin Beta 3 / CD61 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123329

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.06 kDa

Price:

100 µg/$710

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Mouse ITGB3 / Integrin Beta 3 / CD61 Protein (Recombinant His-S) (aa135-377) - LS-G13588

Source:

E. coli

Tag:

His-S

Molecular Weight:

32.7 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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Human ITGB3 / Integrin Beta 3 / CD61 Protein (Over-Expression Lysate His, N-Terminal) (Gly27-Asp718) - LS-G96951

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~76 kDa

Price:

100 µg/$298

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Human ITGB3 / Integrin Beta 3 / CD61 Protein (Over-Expression Cell Culture Supernatant His, N-Terminal) (Gly27-Asp718) - LS-G96952

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~76 kDa

Price:

200 µl/$283

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Human ITGB3 / Integrin Beta 3 / CD61 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81375

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.06 kDa

Price:

20 µg/$215

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Human ITGB3 / Integrin Beta 3 / CD61 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68068

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84.3 kDa

Price:

20 µg/$1,107

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