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ITGB2 / CD18

integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.

Gene Name: integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGB2, CD18 antigen, CD18, Integrin beta chain, beta 2, LCAMB, MAC-1, MFI7, MF17, Integrin beta-2, LAD, LFA-1
Target Sequences: NM_000211 NP_000202.3 P05107

Publications (3)

1
Multiple receptors trigger human NK cell-mediated cytotoxicity against porcine chondrocytes. Sommaggio R, Cohnen A, Watzl C, Costa C. Journal of immunology (Baltimore, Md. : 1950). 2012 188:2075-83. [PubMed:22287712] Related Antibodies: LS-C40959.
2
Actinobacillus pleuropneumoniae exotoxin ApxI induces cell death via attenuation of FAK through LFA-1. Siou-Cen Li, Yu-Tsen Cheng, Ching-Yang Wang, Jia-Ying Wu, Zeng-Weng Chen, Jyh-Perng Wang, Jiunn-Horng Lin, Shih-Ling Hsuan. Scientific reports. 2021 January;11:1753. [Full Text Article] [PubMed:33462305] [PMC:PMC7813829] Related Antibodies: LS-C312785.
3
Expression of adhesion, attachment and invasion markers in eutopic and ectopic endometrium: a link to the aetiology of endometriosis. Sundqvist J, Andersson KL, Scarselli G, Gemzell-Danielsson K, Lalitkumar PG. Human reproduction (Oxford, England). 2012 Sep;27:2737-46. [Full Text Article] [PubMed:22767451] Related Antibodies: LS-B1849.

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Proteins (14)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (5)
Recombinant (8)
ITGB2 / CD18 (14)
No (14)
GST (2)
GST, N-terminus (1)
His, N-Terminal (2)
His-GST (1)
His-MBP (1)
His-T7 (2)
Myc-DDK (Flag) (5)
Human (10)
Mouse (1)
Rat (1)
293T Cells (2)
E. coli (4)
HEK 293 Cells (5)
Wheat Germ Extract (3)
Purified (2)
Supernatant (1)
ITGB2 / CD18 Protein
Select
E. coli
His-T7
27.9 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
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HEK 293 Cells
His, N-Terminal
~75 kDa
100 µg/$298
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HEK 293 Cells
His, N-Terminal
~75 kDa
200 µl/$283
ITGB2 / CD18 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
84.79 kDa
100 µg/$494
ITGB2 / CD18 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
84.78 kDa
100 µg/$710
ITGB2 / CD18 Protein - Recombinant Integrin Beta 2 By SDS-PAGE
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E. coli
His-MBP
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
ITGB2 / CD18 Protein - Recombinant Integrin Beta 2 By SDS-PAGE
Select
E. coli
His-GST
58.8 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
ITGB2 / CD18 Protein - Recombinant Integrin Beta 2 By SDS-PAGE
Select
E. coli
His-T7
32.8 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
ITGB2 / CD18 Protein - 12.5% SDS-PAGE of human ITGB2 stained with Coomassie Blue
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Wheat Germ Extract
GST
110.33 kDa
10 µg/$479; 25 µg/$670
ITGB2 / CD18 Protein - 12.5% SDS-PAGE of human ITGB2 stained with Coomassie Blue
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Wheat Germ Extract
GST
111.2 kDa
10 µg/$479; 25 µg/$670
ITGB2 / CD18 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ITGB2 / CD18 Protein - Purified recombinant protein ITGB2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
82.5 kDa
20 µg/$1,107
ITGB2 / CD18 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
84.79 kDa
20 µg/$150
ITGB2 / CD18 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
84.78 kDa
20 µg/$215
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).