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ITGAM / CD11b
integrin, alpha M (complement component 3 receptor 3 subunit)
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
| Gene Name: | integrin, alpha M (complement component 3 receptor 3 subunit) |
| Family/Subfamily: | Integrin , not assigned-Integrin |
| Synonyms: | ITGAM, Antigen CD11b (p170), CD11B, CD11b antigen, CR3A, Integrin alpha-M, MAC-1, MO1A, Neutrophil adherence receptor, MAC1A, SLEB6, CR-3 alpha chain |
| Target Sequences: | NM_000632 NP_000623.2 P11215 |
Publications (21)
1
Dissection of the hyperadhesive phenotype of airway eosinophils in asthma. Barthel SR, Jarjour NN, Mosher DF, Johansson MW. American journal of respiratory cell and molecular biology. 2006 35:378-86.
[PubMed:16601240]
[PMC:PMC1550734]
Related Antibodies: LS-C40808.
2
Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia. Pillay J, Ramakers BP, Kamp VM, Loi AL, Lam SW, Hietbrink F, Leenen LP, Tool AT, Pickkers P, Koenderman L. Journal of leukocyte biology. 2010 88:211-20.
[PubMed:20400675]
Related Antibodies: LS-C40808.
3
Basophils and the T helper 2 environment can promote the development of lupus nephritis. Charles N, Hardwick D, Daugas E, Illei GG, Rivera J. Nature medicine. 2010 16:701-7.
[PubMed:20512127]
[PMC:PMC2909583]
Related Antibodies: LS-C40807.
☰ Filters
Products
Proteins
(14)
Type
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(3)
Recombinant
(10)
Target
ITGAM / CD11b
(14)
Publications
No
(14)
Tag
6His, C-terminus
(1)
GST, N-terminus
(1)
His
(6)
His, N-Terminal
(2)
His-GST
(1)
Myc-DDK (Flag)
(3)
Species
Human
(8)
Mouse
(2)
Rat
(3)
Source
293T Cells
(1)
E. coli
(7)
HEK 293 Cells
(4)
Human
(1)
Wheat Germ Extract
(1)
Purification
Supernatant
(1)
Low Endotoxin Level
Low endotoxin level
(1)
293T Cells
Myc-DDK (Flag)
127.18 kDa
20 µg/$215
E. coli
His
21.4 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
E. coli
His
18.2 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
125.4 kDa
20 µg/$1,107
HEK 293 Cells
His, N-Terminal
~123 kDa
200 µl/$283
HEK 293 Cells
His, N-Terminal
~123 kDa
100 µg/$298
Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
121.4 kDa
10 µg/$349; 50 µg/$682
HEK 293 Cells
Myc-DDK (Flag)
127.18 kDa
100 µg/$710
E. coli
His
16.7 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
His
15.3 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
E. coli
His-GST
43.7 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
His
15.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
His
12.8 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
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product results
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