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6737 Mowry Ave
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ITGA8 / Integrin Alpha 8
integrin, alpha 8
Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms.
| Gene Name: | integrin, alpha 8 |
| Family/Subfamily: | Integrin , not assigned-Integrin |
| Synonyms: | ITGA8, Integrin, alpha 8, Integrin alpha-8 |
| Target Sequences: | L36531 AAA93514.1 P53708 |
Publications (2)
1
Robust isolation of malignant plasma cells in multiple myeloma. Frigyesi I, Adolfsson J, Ali M, Christophersen MK, Johnsson E, Turesson I, Gullberg U, Hansson M, Nilsson B. Blood. 2014 123:1336-40. (Flo; Human)
[Full Text Article]
[PubMed:24385542]
Related Antibodies: LS-C130071.
2
An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells. Qing Chen, Peishun Shou, Liying Zhang, Chunliang Xu, Chunxing Zheng, Yanyan Han, Wenzhao Li, Yin Huang, Xiaoren Zhang, Changshun Shao, Arthur I Roberts, Arnold B Rabson, Guangwen Ren, Yanyun Zhang, Ying Wang, David T Denhardt, Yufang Shi. Stem cells (Dayton, Ohio). 2014 February;32:327-37. [Full Text Article]
[PubMed:24123709]
[PMC:PMC3961005]
Related Antibodies: LS-C36922.
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ITGA8 / Integrin Alpha 8
(40)
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(33)
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(11)
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(3)
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(1)
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(3)
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(32)
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rabbit
(25)
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(8)
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(12)
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(2)
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monoclonal mc
(8)
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(27)
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(1)
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(4)
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(5)
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(4)
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(4)
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(4)
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(7)
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(38)
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(2)
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(1)
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(1)
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(3)
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ITGA8 / Integrin Alpha 8 Goat anti-Mouse Polyclonal (aa38-1007) Antibody
Mouse
ICC, WB
Unconjugated
100 µg/$962
ITGA8 / Integrin Alpha 8 Goat anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ICC, WB
Biotin Conjugated
50 µg/$1,043
ITGA8 / Integrin Alpha 8 Mouse anti-Human Monoclonal (aa610-800) (APC) Antibody
Human
Flo
APC Conjugated
100 Tests/$907
ITGA8 / Integrin Alpha 8 Rabbit anti-Human Polyclonal (aa1025-1053) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
ITGA8 / Integrin Alpha 8 Rabbit anti-Human Polyclonal (aa1025-1053) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
ITGA8 / Integrin Alpha 8 Rabbit anti-Human Polyclonal (aa1025-1053) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
ITGA8 / Integrin Alpha 8 Rabbit anti-Human Polyclonal (aa1025-1053) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
ITGA8 / Integrin Alpha 8 Rabbit anti-Human Polyclonal (aa1025-1053) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
ITGA8 / Integrin Alpha 8 Rabbit anti-Human Polyclonal (aa1025-1053) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
ITGA8 / Integrin Alpha 8 Rabbit anti-Human Polyclonal (aa1025-1053) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
ITGA8 / Integrin Alpha 8 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ITGA8 / Integrin Alpha 8 Mouse anti-Human Monoclonal (aa836-936) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
ITGA8 / Integrin Alpha 8 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
ITGA8 / Integrin Alpha 8 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
ITGA8 / Integrin Alpha 8 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$904
ITGA8 / Integrin Alpha 8 Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
ITGA8 / Integrin Alpha 8 Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$904
ITGA8 / Integrin Alpha 8 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ITGA8 / Integrin Alpha 8 Mouse anti-Human Monoclonal (aa610-800) (PE) Antibody
Human
Flo
PE Conjugated
100 Tests/$824
ITGA8 / Integrin Alpha 8 Rabbit anti-Human Polyclonal (aa251-300) Antibody
Human
WB
Unconjugated
100 µl/$424
ITGA8 / Integrin Alpha 8 Rabbit anti-Human Polyclonal (aa251-300) (FITC) Antibody
Zebrafish, Mouse, Dog, Rat, Pig, Human, Chimpanzee
WB
FITC Conjugated
100 µl/$469
ITGA8 / Integrin Alpha 8 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human, Monkey
WB
Unconjugated
100 µl/$299
ITGA8 / Integrin Alpha 8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
ITGA8 / Integrin Alpha 8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
ITGA8 / Integrin Alpha 8 Rabbit anti-Human Polyclonal (aa907-1063) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
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