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ITGA7 / Integrin Alpha 7

integrin, alpha 7

ITGA7 encodes integrin alpha chain 7. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 7 undergoes post-translational cleavage within the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that binds to the extracellular matrix protein laminin-1. Alpha 7 beta 1 is the major integrin complex expressed in differentiated muscle cells. Splice variants of alpha 7 that differ in both the extracellular and cytoplasmic domains exist in the mouse; however, to date only a single human transcript type has been isolated: it contains extracellular and cytoplasmic domains corresponding to the mouse X2 and B variants, respectively. A unique extracellular splice variant has been identified in human, although it clearly represents a minor species and its biological significance is unclear.

Gene Name: integrin, alpha 7
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGA7, Alpha 7b integrin, Integrin alpha-7, Integrin alpha 7 chain, Integrin, alpha 7
Target Sequences: NM_002206 NP_002197.2 Q13683

Publications (3)

1
Maintaining bovine satellite cells stemness through p38 pathway. Ding S, Swennen GNM, Messmer T, Gagliardi M, Molin DGM, Li C, Zhou G, Post MJ. Scientific reports. 2018 July;8:10808. (Human) [Full Text Article] [PubMed:30018348] [PMC:PMC6050236] Related Antibodies: LS-C313325.
2
Integrins functioning in uterine endometrial stromal and epithelial cells in estrus. Hye Jin Park, Ji Eun Park, Hyun Lee, Seong Jae Kim, Jung Im Yun, Minseok Kim, Kyu Hyun Park, Seung Tae Lee. Reproduction (Cambridge, England). 2017 Mar;153:351-360. [Full Text Article] [PubMed:27998942] Related Antibodies: LS-C179570.
3
Laminin a2 controls mouse and human stem cell behaviour during midbrain dopaminergic neuron development. Maqsood Ahmed, Leandro N Marziali, Ernest Arenas, M Laura Feltri, Charles Ffrench-Constant. Development (Cambridge, England). 2019 Aug;146:dev172668. [Full Text Article] [PubMed:31371375] [PMC:PMC6737905]

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ITGA7 / Integrin Alpha 7 (1)
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Wheat Germ Extract (1)
ITGA7 / Integrin Alpha 7 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).