IRF7

interferon regulatory factor 7

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.

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Antibodies (32)

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ELISA Kits (3)

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Primary (32)

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IRF7 (41)

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polyclonal pc (26)

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IHC-plus™ IRF7 Antibody (aa1-150, clone 3D9) LS-B2945

(5.0) Rating

(1) Publication(s)

Antibody:

IRF7 Mouse anti-Human Monoclonal (aa1-150) (3D9) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ IRF7 Antibody LS-B577

(4.0) Rating

Antibody:

IRF7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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IHC-plus™ IRF7 Antibody LS-B1372

(4.0) Rating

Antibody:

IRF7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$545

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IRF7 Antibody (C-Terminus, HRP) LS-C436969

Antibody:

IRF7 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Dog, Human, Monkey, Chimpanzee, Orangutan, Gibbon

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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IRF7 Antibody (C-Terminus, Biotin) LS-C436951

Antibody:

IRF7 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

• HRP
• Biotin

• HRP
• Biotin

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IRF7 Antibody LS-C499135

Antibody:

IRF7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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IRF7 Antibody (HRP) LS-C499143

Antibody:

IRF7 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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IRF7 Antibody (Biotin) LS-C499133

Antibody:

IRF7 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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IRF7 Antibody (FITC) LS-C499142

Antibody:

IRF7 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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Mouse IRF7 (Sandwich ELISA) ELISA Kit - LS-F65743

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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IRF7 Antibody LS-C666496

Antibody:

IRF7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$351

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Human IRF7 (Sandwich ELISA) ELISA Kit - LS-F52125

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

23.4 - 1500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$897

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Human IRF7 (Sandwich ELISA) ELISA Kit - LS-F66657

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Select

IRF7 Antibody LS-C809682

Antibody:

IRF7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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IRF7 Antibody (clone 3D9) LS-C745904

Antibody:

IRF7 Mouse anti-Human Monoclonal (3D9) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$518

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IRF7 Antibody LS-C779031

Antibody:

IRF7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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IRF7 Antibody (HRP) LS-C547259

Antibody:

IRF7 Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

100 µl/$887

Select

IRF7 Antibody (Biotin) LS-C527154

Antibody:

IRF7 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

100 µl/$887

Select

IRF7 Antibody (FITC) LS-C537131

Antibody:

IRF7 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

100 µl/$887

Select

IRF7 Antibody (PE) LS-C655307

Antibody:

IRF7 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

100 µl/$887

• HRP
• Biotin
• FITC
• PE

• HRP
• Biotin
• FITC
• More...
  • PE

Select

IRF7 Antibody LS-C832767

Antibody:

IRF7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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IRF7 Antibody (aa35-84) LS-C110267

Antibody:

IRF7 Rabbit anti-Human Polyclonal (aa35-84) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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IRF7 Antibody LS-C667865

Antibody:

IRF7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

Select

IRF7 Antibody (FITC) LS-C537130

Antibody:

IRF7 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$973

Select

IRF7 Antibody (FITC) LS-C537132

Antibody:

IRF7 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$896

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