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IREB2 / IRP2
iron-responsive element binding protein 2
RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
| Gene Name: | iron-responsive element binding protein 2 |
| Synonyms: | IREB2, ACO3, Iron regulatory protein 2, IRP2AD, IRE-BP 2, IRP2 |
| Target Sequences: | NM_004136 P48200 P48200 |
Publications (7)
1
Regulation of iron metabolism in Hamp (-/-) mice in response to iron-deficient diet. Masaratana P, Patel N, Latunde-Dada GO, Vaulont S, Simpson RJ, McKie AT. European journal of nutrition. 2013 52:135-43. (WB; Mouse)
[PubMed:22241739]
2
Alterations in renal iron metabolism caused by a copper/zinc-superoxide dismutase deficiency. Yoshihara D, Fujiwara N, Kato S, Sakiyama H, Eguchi H, Suzuki K. Free radical research. 2012 46:750-7. (WB; Mouse)
[PubMed:22435664]
3
Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia. Whitnall M, Suryo Rahmanto Y, Huang ML, Saletta F, Lok HC, Gutirrez L, Lzaro FJ, Fleming AJ, St Pierre TG, Mikhael MR, Ponka P, Richardson DR. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:20590-5. (WB; Mouse)
[PubMed:23169664]
[PMC:PMC3528580]
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IREB2 / IRP2 Rabbit anti-Mouse Polyclonal (aa100-200) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
IREB2 / IRP2 Rabbit anti-Mouse Polyclonal (Internal) (Biotin) Antibody
Mouse
ICC, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
IREB2 / IRP2 Rabbit anti-Mouse Polyclonal (Internal) (DY650) Antibody
Mouse
ICC, IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
IREB2 / IRP2 Rabbit anti-Mouse Polyclonal (Internal) (DY550) Antibody
Mouse
ICC, IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
IREB2 / IRP2 Rabbit anti-Mouse Polyclonal (Internal) (DY488) Antibody
Mouse
ICC, IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
IREB2 / IRP2 Goat anti-Human Polyclonal (aa489-503) Antibody
Pig, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
IREB2 / IRP2 Rabbit anti-Human Polyclonal (aa434-483) Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µl/$424
IREB2 / IRP2 Rabbit anti-Human Polyclonal (aa201-230) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
IREB2 / IRP2 Rabbit anti-Rat Polyclonal (aa1-343) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
IREB2 / IRP2 Rabbit anti-Mouse Polyclonal (Internal) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$649
IREB2 / IRP2 Rabbit anti-Human Polyclonal (aa201-230) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
IREB2 / IRP2 Rabbit anti-Human Polyclonal (aa201-230) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
200 µl/$952
IREB2 / IRP2 Rabbit anti-Human Polyclonal (aa201-230) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
IREB2 / IRP2 Rabbit anti-Human Polyclonal (aa201-230) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
IREB2 / IRP2 Rabbit anti-Human Polyclonal (aa201-230) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
IREB2 / IRP2 Rabbit anti-Human Polyclonal (aa201-230) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
IREB2 / IRP2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
E. coli
6His, N-terminus
40.9 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
IREB2 / IRP2 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
![IREB2 / IRP2 Antibody - Immunofluorescence of monoclonal antibody to IREB2 on HeLa cell . [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/ireb2-irp2-antibody-clone-1f3-ls-c197544/145429_4915441.jpg)
IREB2 / IRP2 Mouse anti-Human Monoclonal (1F3) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
IREB2 / IRP2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$341
IREB2 / IRP2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$832
IREB2 / IRP2 Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
IREB2 / IRP2 Rabbit anti-Rat Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µl/$801
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