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IPO5 / RANBP5
importin 5
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
| Gene Name: | importin 5 |
| Synonyms: | IPO5, IMB3, Importin 5, Importin subunit beta-3, Imp5, Importin-5, Importin beta-3 subunit, Karyopherin beta-3, KPNB3, Karyopherin (importin) beta 3, Pse1, RAN binding protein 5, Ran-binding protein 5, Ran_GTP binding protein 5, RANBP5 |
| Target Sequences: | NM_002271 NP_002262.3 O00410 |
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