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The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
Gene Name: | inhibin, beta B |
Family/Subfamily: | TGF beta , not assigned-TGF beta |
Synonyms: | INHBB, Activin beta-B chain, Activin AB beta polypeptide, Inhibin, beta B, Inhibin Beta B, Inhibin beta B chain, Inhibin, beta-2 |
Target Sequences: | NM_002193 NP_002184.2 P09529 |
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