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Influenza A H5N2 NS2
Influenza A Virus H5N2 Nonstructural Protein 1
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs to which the M1 protein is bound. Because the M1 protein is not available in large quantities until the later stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the nucleus before sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enters the cytoplasm only when they have associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.
| Gene Name: | Influenza A Virus H5N2 Nonstructural Protein 1 |
| Family/Subfamily: | Virulence Factor |
| Synonyms: | NEP, NS2, NS2-H5N1, Influenza A NS2 |
| Target Sequences: | AAD51931.1 |
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