IMPA1 / IMP

inositol(myo)-1(or 4)-monophosphatase 1

IMPA1 / IMP is an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

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Products

Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

IMPA1 / IMP (10)

Publications

No (10)

Tag

6His, N-terminus (2)

GST (1)

His (2)

Myc-DDK (Flag) (5)

Species

Human (8)

Source

293T Cells (2)

E. coli (4)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

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Human IMPA1 / IMP Protein (Recombinant GST) (Full Length) - LS-G29058

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

56.21 kDa

Price:

10 µg/$479; 25 µg/$670

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Human IMPA1 / IMP Protein (Recombinant 6His, N-terminus) (Met1-Asp277) - LS-G38767

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

32.3kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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Human IMPA1 / IMP Protein (Recombinant His) - LS-G959

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human IMPA1 / IMP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77514

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.5 kDa

Price:

20 µg/$150

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Human IMPA1 / IMP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77515

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30 kDa

Price:

20 µg/$150

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IMPA1 / IMP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115904

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30 kDa

Price:

100 µg/$494

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Human IMPA1 / IMP Protein (Recombinant 6His, N-terminus) (Met1-Asp277) - LS-G140219

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

32.3 kDa

Price:

10 µg/$344; 50 µg/$584

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IMPA1 / IMP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G126373

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.5 kDa

Price:

100 µg/$494

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Human IMPA1 / IMP Protein (Recombinant His) (Met1-Asp277) - LS-G97620

Source:

E. coli

Tag:

His

Molecular Weight:

32.4 kDa

Price:

100 µg/$843

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Human IMPA1 / IMP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66342

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30 kDa

Price:

20 µg/$1,107

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