ILKAP

integrin-linked kinase-associated serine/threonine phosphatase

Integrin-linked kinase-associated phosphatase 2C (ILKAP), a PP2C type serine/threonine phosphatase, is a monomeric enzyme composed of a catalytic and noncatalytic domain. The dephosphorylation catalytic activity is sensitive to manganese and magnesium. ILKAP has been found to associate with the integrin-linked kinase 1 (ILK1). It downregulates integrin and growth factor stimulated ILK1 activity. It is believed to target ILK1 signalling of the Wnt pathway via modulation of GSK3beta phosphorylation. Over-expression of ILKAP in mammalian cells has been found to result in inhibition of cell cycle progression.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

ILKAP (6)

Publications

No (6)

Tag

GST (1)

His (1)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Human Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human ILKAP Protein (Recombinant His-SUMO) (Full Length) - LS-G20872

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

58.9 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human ILKAP Protein (Recombinant His) (Met1-His392) - LS-G97619

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

44.3 kDa

Price:

100 µg/$843

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Human ILKAP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69265

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.7 kDa

Price:

20 µg/$1,107

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Human ILKAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84216

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.7 kDa

Price:

20 µg/$150

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ILKAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101960

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.7 kDa

Price:

100 µg/$494

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Human ILKAP Protein (Recombinant GST) (Full Length) - LS-G35475

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

68.86 kDa

Price:

10 µg/$479; 25 µg/$670

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