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IL7

interleukin 7

IL7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.

Gene Name: interleukin 7
Family/Subfamily: IL-7/ IL-9 , not assigned-IL-7/ IL-9
Synonyms: IL7, IL-7, Interleukin-7, Interleukin 7
Target Sequences: NM_000880 NP_000871.1 P13232

Publications (1)

1
Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping. Nicolas Severe, Nezihi Murat Karabacak, Karin Gustafsson, Ninib Baryawno, Gabriel Courties, Youmna Kfoury, Konstantinos D Kokkaliaris, Catherine Rhee, Dongjun Lee, Elizabeth W Scadden, Juan Esteban Garcia-Robledo, Thomas Brouse, Matthias Nahrendorf, Mehmet Toner, David T Scadden. Cell stem cell. 2019 October;25:570-583.e7. [Full Text Article] [PubMed:31279774] [PMC:PMC6778015] Related Antibodies: LS-B14351.

☰ Filters
Products
Proteins (35)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (31)
IL7 (35)
Animal-free (1)
No (35)
6His, C-terminus (6)
6His-SUMO, N-terminus (1)
8His, C-terminus (1)
GST (1)
His (2)
His, C-Terminal (2)
His, N-Terminal (3)
His,C-terminus (1)
His-T7 (1)
Human Mutant IgG1 Fc (1)
Myc-DDK (Flag) (2)
Human (23)
Mouse (9)
Rat (2)
293T Cells (1)
CHO Cells (3)
E. coli (17)
HEK 293 Cells (5)
Human Cells (2)
Insect Cells (1)
Mammalian Cells (4)
Wheat Germ Extract (1)
Purified (12)
Low endotoxin level (22)
Biologically active (17)
Animal-free (1)
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
18.4kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
Select
CHO Cells
Human Mutant IgG1 Fc
Biologically active
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$519
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
15.0 kDa
2 µg/$262; 10 µg/$335
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
15.0 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.4 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$281; 10 µg/$369
IL7 Protein
Select
E. coli
None
Biologically active
17.4 kDa
10 µg/$388; 100 µg/$1,466; 500 µg/$3,025
IL7 Protein
Select
E. coli
None
Biologically active
14.9 kDa
10 µg/$388; 100 µg/$1,466; 500 µg/$3,025
IL7 Protein - 12.5% SDS-PAGE of human IL7 stained with Coomassie Blue
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Wheat Germ Extract
GST
42.46 kDa
10 µg/$479; 25 µg/$670
Select
None
17.4KD
10 µg/$484
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.5kD
10 µg/$321; 50 µg/$534; 500 µg/$1,869; 1 mg/$2,991
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
15.9kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
IL7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.19 kDa
20 µg/$150
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
17.4 kDa
10 µg/$364; 1 mg/$4,545
IL7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
20.19 kDa
100 µg/$494
IL7 Protein
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~17.7 kDa
10 µg/$291; 100 µg/$731; 1 mg/$8,695
Select
HEK 293 Cells
His,C-terminus
Biologically active
Less than 0.01 EU/µg protein (determined by LAL method).
~27 kDa (SDS-PAGE)
10 µg/$358; 50 µg/$690
IL7 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
15.9 kDa
50 µg/$698; 10 µg/$356; 1 mg/$3,095; 500 µg/$1,987
IL7 Protein - Proliferation of PHA-activated human PBL induced by human IL-7.
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HEK 293 Cells
8His, C-terminus
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 152 amino acid recombinant protein has a predicted molecular mass of approximately 18.8 kD. The DTT-reduced and non-reduced protein migrate at approximately 20- 30 kD by SDS-PAGE. The C-terminal contains an 8His-(TG8HGGQ)-tag.
10 µg/$352; 25 µg/$459; 100 µg/$1,065; 500 µg/$2,285
IL7 Protein - PHA activated PBL proliferation induced by mouse IL-7.
Select
Insect Cells
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 148 amino acid recombinant protein (with ADL-His9-SSGIEGR at N-terminus) has a predicted molecular mass of approximately 17 kD. The DTT-reduced and non-reduced protein migrates at approximately 20 kD by SDS-PAGE.
10 µg/$352; 25 µg/$459
IL7 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
17.5 kDa
50 µg/$698; 10 µg/$356; 1 mg/$3,932; 500 µg/$2,459
IL7 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
18.4 kDa
50 µg/$698; 10 µg/$356; 1 mg/$3,095; 500 µg/$2,167
Select
HEK 293 Cells
His, N-Terminal
~17 kDa
200 µl/$283
Select
HEK 293 Cells
His, N-Terminal
~17 kDa
100 µg/$298
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
10 µg/$395
Viewing 1-25 of 35 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).