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IL6 / Interleukin 6

interleukin 6 (interferon, beta 2)

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

Gene Name:	interleukin 6 (interferon, beta 2)
Family/Subfamily:	Hormone , not assigned-Hormone
Synonyms:	IL6, B-cell stimulatory factor 2, BSF-2, BSF2, CTL differentiation factor, Hybridoma growth factor, IFN-beta-2, Interleukin-6, Interleukin BSF-2, IFNB2, B-cell differentiation factor, CDF, HSF, IL-6
Target Sequences:	NM_000600 NP_000591.1 P05231

Publications (18)

Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice. Chen C, Liu Y, Liu Y, Zheng P. The Journal of clinical investigation. 2010 120:4091-101. (Mouse) [PubMed:20972332] [PMC:PMC2964994] Related Antibodies: LS-C7955.

Fetal skin as a pro-inflammatory organ: Evidence from a primate model of chorioamnionitis. Boonkasidecha S, Kannan PS, Kallapur SG, Jobe AH, Kemp MW. PloS one. 2017 September;12:e0184938. (Human) [Full Text Article] [PubMed:28957335] [PMC:PMC5619751] Related Antibodies: LS-B7482.

Contribution of the Interleukin-6/STAT-3 Signaling Pathway to Chondrogenic Differentiation of Human Mesenchymal Stem Cells. Kondo M, Yamaoka K, Sakata K, Sonomoto K, Lin L, Nakano K, Tanaka Y. Arthritis & rheumatology (Hoboken, N.J.). 2015 May;67:1250-60. [Full Text Article] [PubMed:25604648]

Oleoylethanolamide treatment reduces neurobehavioral deficits and brain pathology in a mouse model of Gulf War Illness. Joshi U, Evans JE, Joseph R, Emmerich T, Saltiel N, Lungmus C, Oberlin S, Langlois H, Ojo J, Mouzon B, Paris D, Mullan M, Jin C, Klimas N, Sullivan K, Crawford F, Abdullah L. Scientific reports. 2018 August;8:12921. [Full Text Article] [PubMed:30150699] [PMC:PMC6110778]

The Morphopathogenetic Aspects of Intraabdominal Adhesions in Children under One Year of Age. Junga A, Pilmane M, Abola Z, Volrats O. Medicina (Kaunas). 2019 August;55:E556. [Full Text Article] [PubMed:31480453] [PMC:PMC6780280] Related Antibodies: LS-B1582.

IL-6 release from muscles during exercise is stimulated by lactate-dependent protease activity. Pernille Hojman, Camilla Brolin, Nynne Nørgaard-Christensen, Christine Dethlefsen, Britt Lauenborg, Cecilie Køllner Olsen, Mette Marie Åbom, Thomas Krag, Julie Gehl, Bente Klarlund Pedersen. American journal of physiology. Endocrinology and metabolism. 2019 May;316:E940-E947. [Full Text Article] [PubMed:30779630]

Mystery Solved: Why Smoke Extract Worsens Disease in Smokers with Crohn's Disease and Not Ulcerative Colitis? Gut MAP!. Dania AlQasrawi, Latifa S Abdelli, Saleh A Naser. Microorganisms. 2020 May;8:666. [Full Text Article] [PubMed:32370298] [PMC:PMC7284734]

Effects of arginase inhibition via jugular infusion of N?-hydroxy-nor-l-arginine on metabolic and immune indices in lactating dairy cows. L Y Ding, Y F Wang, Y Z Shen, G Zhou, X Zhang, M Z Wang, J J Loor, J Zhang. Journal of dairy science. 2019 Apr;102:3310-3320. [Full Text Article] [PubMed:30738683]

Inhibition of lncRNA H19/miR-370-3p pathway mitigates neuronal apoptosis in an in vitro model of spinal cord injury (SCI). Xin Li, Yan Qian, Kaihua Tang, Yang Li, Rui Tao, Chunyan Gong, Li Huang, Kaiwen Zou, Lindong Liu. Translational neuroscience. 2021 Mar;12:103-113. [Full Text Article] [PubMed:33708438] [PMC:PMC7925972] Related Antibodies: LS-C746886.

Increased IL-6 expression precedes reliable viral detection in the rhesus macaque brain during acute SIV infection. Raja Mohan Gopalakrishnan, Malika Aid, Noe B Mercado, Caitlin Davis, Shaily Malik, Emma Geiger, Valerie Varner, Rhianna Jones, Steven E Bosinger , Cesar Piedra-Mora, Amanda J Martinot , Dan H Barouch , R Keith Reeves , C Sabrina Tan. JCI insight. 2021 Oct;6:e152013. [Full Text Article] [PubMed:34676832] [PMC:PMC8564899] Related Antibodies: LS-A9692.

Histamine promotes adhesion of neutrophils by inhibition of autophagy in dairy cows with subacute ruminal acidosis. Kexin Wang, Zhenai Sun, Yunfei Li, Mingchao Liu, Juan J Loor, Qianming Jiang, Guowen Liu, Zhe Wang, Yuxiang Song, Xinwei Li. Journal of dairy science. 2022 September;105:7600-7614. [Full Text Article] [PubMed:35940921]

Cancer-Associated Exosomal CBFB Facilitates the Aggressive Phenotype, Evasion of Oxidative Stress, and Preferential Predisposition to Bone Prometastatic Factor of Breast Cancer Progression. Chia-Hung Hsu, Hon-Ping Ma, Jiann Ruey Ong, Ming-Shou Hsieh, Vijesh Kumar Yadav, Chi-Tai Yeh, Tsu-Yi Chao, Wei-Hwa Lee, Wen-Chien Huang, Kuang-Tai Kuo, Iat-Hang Fong, Chih-Cheng Lin, Chih-Ming Su. Disease Markers. 2022 July;2022:8446629. [Full Text Article] [PubMed:35903297] [PMC:PMC9325341]

Potentilla chinensis aqueous extract attenuates cyclophosphamide-induced hemorrhagic cystitis in rat model. Kajetan Juszczak, Jan Adamowicz, Lukasz Zapala, Tomasz Kluz, Przemyslaw Adamczyk, Artur Wdowiak, Iwona Bojar, Marcin Misiek, Magdalena Emilia Grzybowska, Klaudia Stangel-Wójcikiewicz, Ewa Poleszak, Marta Pokrywczynska, Tomasz Drewa, Andrzej Wróbel. Scientific reports. 2022 July;12:13076. [Full Text Article] [PubMed:35906474] [PMC:PMC9338276]

Aberrant blood cell division cycle 42 expression and its correlation with disease severity, inflammation and mortality risk in patients with acute pancreatitis. Jun Yang, Xiaoqian Li, Xuefeng Yang, Hongjiang Wei, Lipu Deng, Nian Fu. Experimental and therapeutic medicine. 2022 July;24:458. [Full Text Article] [PubMed:35747149] [PMC:PMC9204537]

Free fatty acids promote degranulation of azurophil granules in neutrophils by inducing production of NADPH oxidase-derived reactive oxygen species in cows with subclinical ketosis. Yuxiang Song, Shang Jiang, Congyi Li, Juan J Loor, Qianming Jiang, Yuchen Yang, Xiancheng Feng, Siyuan Liu, Jiyuan He, Kexin Wang, Yunfei Li, Cai Zhang, Xiliang Du, Zhe Wang, Xinwei Li, Guowen Liu. Journal of dairy science. 2022 March;105:2473-2486. [Full Text Article] [PubMed:34998570]

Green Synthesis of Silver Nanoparticles by the Cyanobacteria Synechocystis sp.: Characterization, Antimicrobial and Diabetic Wound-Healing Actions. Nancy S Younis, Maged E Mohamed, Nermin A El Semary. Marine drugs. 2022 January;20:56. [Full Text Article] [PubMed:35049911] [PMC:PMC8781738]

LncRNA H19 aggravates TNF-a-induced inflammatory injury via TAK1 pathway in MH7A cells. Jialiang Yang, Yixuan Li, Lili Wang, Zhenchun Zhang, Zunzhong Li, Qian Jia. BioFactors (Oxford, England). 2020 September;46:813-820. [Full Text Article] [PubMed:32525617] Related Antibodies: LS-B7482.

Effects of a Peptide Derived from the Primary Sequence of a Kallikrein Inhibitor Isolated from Bauhinia bauhinioides (pep-BbKI) in an Asthma-COPD Overlap (ACO) Model. Luana Laura Sales da Silva, Jéssica Anastácia Silva Barbosa, Juliana Morelli Lopes Gonçalves João, Silvia Fukuzaki, Leandro do Nascimento Camargo, Tabata Maruyama Dos Santos, Elaine Cristina de Campos, Arthur Silva Costa, Beatriz Mangueira Saraiva-Romanholo, Suellen Karoline Moreira Bezerra, Fernanda Tenório Quirino Dos Santos Lopes, Camila Ramalho Bonturi, Maria Luiza Vilela Oliva, Edna Aparecida Leick, Renato Fraga Righetti, Iolanda de Fátima Lopes Calvo Tibério. International journal of molecular sciences. 2023 July;24: [Full Text Article] [PubMed:37511021] [PMC:PMC10379932] Related Antibodies: LS-C746886.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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