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Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
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Additional Contact Details
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IL3RA / CD123
interleukin 3 receptor, alpha (low affinity)
IL3RA / CD123 is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.
| Gene Name: | interleukin 3 receptor, alpha (low affinity) |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL3RA, CD123 antigen, IL-3 receptor subunit alpha, IL-3R subunit alpha, IL3R, IL3RY, CD123, HIL-3Ra, IL-3R-alpha, IL-3RA, IL3RAY, IL3RX |
| Target Sequences: | NM_002183 NP_002174.1 P26951 |
Publications (1)
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