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IL37 is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.
Gene Name: | interleukin 37 |
Family/Subfamily: | IL-1 , not assigned-IL-1 |
Synonyms: | IL37, FIL1, FIL1 zeta, FIL1(ZETA), IL-1 zeta, IL-1F7, IL-1H, IL-1RP1, IL-1X, IL-37, Interleukin-1 homolog 4, Interleukin-1 zeta, Interleukin-1-related protein, Interleukin-23, Interleukin-37, IL1F7, Interleukin 1, zeta, Interleukin-1 family member 7, FIL1Z, IL-1H4, IL1RP1, Interleukin 1 family member 7, Interleukin 37, IL-1X protein, IL1H4, Interleukin-1 superfamily z |
Target Sequences: | NM_014439 NP_055254.2 Q9NZH6 |
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