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The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.
Gene Name: | interleukin 2 receptor, beta |
Family/Subfamily: | Interleukin |
Synonyms: | IL2RB, CD122, CD122 antigen, IL-2 receptor subunit beta, IL15RB, Interleukin 15 receptor, beta, p70-75, IL-2R subunit beta, IL-2RB, Interleukin 2 receptor, beta |
Target Sequences: | NM_000878 NP_000869.1 P14784 |
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