IL1RAP

interleukin 1 receptor accessory protein

Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

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Products

Proteins (17)

Type

Over-Expression Lysate (6)

Recombinant (11)

Target

IL1RAP (17)

Publications

No (17)

Tag

6His, C-terminus (2)

6His, N-terminus (1)

Fc/6His,C-terminus (1)

Fc-6His, C-terminus (1)

GST (1)

His (3)

His,C-terminus (1)

Myc-DDK (Flag) (7)

Species

Human (13)

Mouse (1)

Source

293T Cells (3)

E. coli (3)

HEK 293 Cells (4)

Human (1)

Human Cells (3)

Mammalian Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (6)

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Mouse IL1RAP Protein (Recombinant 6His, N-terminus) (aa21-367) - LS-G25928

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

43.7 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human IL1RAP Protein (Recombinant GST) (Full Length) - LS-G29025

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

64.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human IL1RAP Protein (Recombinant Fc-6His, C-terminus) (Ser21-Gln356) - LS-G39346

Source:

Human Cells

Tag:

Fc-6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

39.7kD

Price:

10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203

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Human IL1RAP Protein (Recombinant His) (Met1-Glu359) - LS-G97597

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

40.7 kDa

Price:

100 µg/$483

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Human IL1RAP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67427

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.8 kDa

Price:

20 µg/$1,107

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Human IL1RAP Protein (Recombinant 6His, C-terminus) (Ser21-Gln356) - LS-G38986

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

39.75kD

Price:

10 µg/$240; 50 µg/$299; 500 µg/$929; 1 mg/$1,245

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IL1RAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107436

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.8 kDa

Price:

100 µg/$494

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IL1RAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130029

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.9 kDa

Price:

100 µg/$494

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IL1RAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99677

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.2 kDa

Price:

100 µg/$710

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Human IL1RAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79817

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.9 kDa

Price:

20 µg/$150

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Human IL1RAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79818

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.2 kDa

Price:

20 µg/$215

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Human IL1RAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79820

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.8 kDa

Price:

20 µg/$150

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Human IL1RAP Protein (Recombinant 6His, C-terminus) - LS-G146189

Source:

Human

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

39.9 kDa

Price:

10 µg/$248; 50 µg/$323

Select

Human IL1RAP Protein (Recombinant Fc/6His,C-terminus) (Ser21-Gln356) - LS-G138623

Source:

Mammalian Cells

Tag:

Fc/6His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

39.7 kDa

Price:

10 µg/$248; 50 µg/$288

Select

Human IL1RAP Protein (Recombinant His,C-terminus) (Ser21-Gln356) - LS-G138669

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

39.75 kDa

Price:

10 µg/$240; 50 µg/$299

Select

Human IL1RAP Protein (Recombinant His) (aa65-249) - LS-G15935

Source:

E. coli

Tag:

His

Molecular Weight:

22.8 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209

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Human IL1RAP Protein (Recombinant His) (aa420-558) - LS-G15938

Source:

E. coli

Tag:

His

Molecular Weight:

17.3 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209

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