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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States

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Customer Service: (800) 227-6666 / (650) 697-3600


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IL18

interleukin 18 (interferon-gamma-inducing factor)

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

Gene Name: interleukin 18 (interferon-gamma-inducing factor)
Family/Subfamily: IL-1 , not assigned-IL-1
Synonyms: IL18, IGIF, IL-1g, Interleukin-18, IFN-gamma-inducing factor, IL-1 gamma, IL-18, Iboctadekin, IL1F4, Interleukin-1 gamma
Target Sequences: NM_001562 NP_001553.1 Q14116

Publications (5)

1
USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation. Palazón-Riquelme P, Worboys JD, Green J, Valera A, Martín-Sánchez F, Pellegrini C, Brough D, López-Castejón G. EMBO reports. 2018 October;19:pii e44766. [Full Text Article] [PubMed:30206189] [PMC:PMC6172458] Related Antibodies: LS-C313397.
2
High Levels of IL-18 and IFN-? in Chronically Inflamed Tissue in Chronic Granulomatous Disease. Meda Spaccamela V, Valencia RG, Pastukhov O, Duppenthaler A, Dettmer MS, Erb J, Steiner UC, Hillinger S, Speckmann C, Ehl S, Reichenbach J, Siler U. Frontiers in immunology. 2019 October;10: [Full Text Article] [PubMed:31681257] [PMC:PMC6813411] Related Antibodies: LS-C313164.
3
Mincle/Syk signaling promotes intestinal mucosal inflammation through induction of macrophage pyroptosis in Crohn's disease. Wenbin Gong, Tao Zheng, Guo Kun, Fang Miao, Haohao Xie, Li Weijie, Qinqing Tang, Zhiwu Hong, Huajian Ren, Guosheng Gu, Gefei Wang, Xiuwen Wu, Yun Zhao, Jianan Ren. Journal of Crohn's & colitis. 2020 April; [Full Text Article] [PubMed:32333776] Related Antibodies: LS-C754834.
4
Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro. Anna Gritsenko, Shi Yu, Fatima Martin-Sanchez, Ines Diaz-Del-Olmo, Eva-Maria Nichols, Daniel M Davis, David Brough, Gloria Lopez-Castejon. Frontiers in immunology. 2020 October;11:565924. [Full Text Article] [PubMed:33101286] [PMC:PMC7555430] Related Antibodies: LS-C313397.
5
Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells. Zhewei Zhao, Xuebin Wang, Rui Zhang, Baitao Ma, Shuai Niu, Xiao Di, Leng Ni, Changwei Liu. Aging. 2021 Apr;13:11363-11380. [Full Text Article] [PubMed:33839695] [PMC:PMC8109127]
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☰ Filters
Products
Proteins (36)
Native (1)
Over-Expression Lysate (2)
Recombinant (33)
IL18 (36)
Product Group
Coronavirus Antibodies Proteins cDNAs (36)
Cytokine Release Syndrome (36)
Cytokine Release Syndrome Proteins (36)
No (36)
10His, N-terminus (2)
6His, C-terminus (3)
6His, N-terminus (5)
GST (2)
His (8)
His, N-Terminal (1)
His-T7 (3)
His-T7, N-terminus (1)
Myc-DDK (Flag) (3)
Bovine (1)
Chicken (1)
Dog (2)
Human (18)
Mouse (7)
Pig (2)
Rabbit (1)
Rat (3)
293T Cells (1)
E. coli (24)
HEK 293 Cells (2)
Human Cells (1)
Mammalian Cells (1)
Mouse (1)
Wheat Germ Extract (1)
Yeast (5)
Purified (15)
Low endotoxin level (12)
Biologically active (2)
IL18 Protein
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~18.5 kDa
25 µg/$291; 100 µg/$452; 1 mg/$3,811
IL18 Protein
Select
E. coli
His
22.1 kD
100 µg/$598; 1 mg/$1,679; 20 µg/$405
Select
E. coli
His
21.7 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
IL18 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
None
22.1 kDa
100 µg/$610; 20 µg/$447; 1 mg/$1,761
IL18 Protein
Select
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$361; 500 µg/$739; 20 µg/$261
IL18 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
1 mg/$1,568; 100 µg/$534; 20 µg/$422
IL18 Protein - Recombinant Interleukin 18 By SDS-PAGE
Select
E. coli
His
19.6 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
IL18 Protein - 12.5% SDS-PAGE of human IL18 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
46.97 kDa
10 µg/$479; 25 µg/$670
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
18.2kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
19.7kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.3kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Select
E. coli
GST
48.6 kDa
50 µg/$556
IL18 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
22.1 kDa
100 µg/$494
Select
293T Cells
Myc-DDK (Flag)
22.1 kDa
20 µg/$150
IL18 Protein - Purified recombinant protein IL18 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
22.1 kDa
20 µg/$1,107
Select
E. coli
None
Less than 0.06 EU/µg protein (determined by LAL method).
~18 kDa
10 µg/$312; 50 µg/$498
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.3 kDa
10 µg/$288; 50 µg/$436
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
18.2 kDa
20 µg/$360; 100 µg/$728
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
19.7 kDa
20 µg/$360; 100 µg/$728
IL18 Protein - Active Interleukin 18 (IL18) by WB
Select
Mouse
His, N-Terminal
19kDa
10 µg/$304; 50 µg/$585; 200 µg/$1,130; 100 µg/$935; 1 mg/$2,333; 500 µg/$1,842; 5 mg/$4,081; 2 mg/$2,526
IL18 Protein - Recombinant Interleukin 18 By SDS-PAGE
Select
E. coli
His-T7
21.7 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
IL18 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His, N-terminus
18 kDa
10 µg/$265; 50 µg/$315
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
18.4 kDa (SDS-PAGE)
50 µg/$512; 10 µg/$296; 1 mg/$4,036
IL18 Protein
Select
E. coli
His
22.3 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
Select
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
50 µg/$498; 10 µg/$312
Viewing 1-25 of 36 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).