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IL17RA
interleukin 17 receptor A
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Gene Name: | interleukin 17 receptor A |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL17RA, CANDF5, CD217 antigen, CDw217, CD217, HIL-17R, IL-17RA, IL17R, Interleukin-17 receptor A, IL-17 receptor, IL-17 receptor A, Interleukin 17 receptor, Interleukin 17 receptor A |
| Target Sequences: | NM_014339 NP_055154.3 Q96F46 |
Publications (3)
1
COX-2 modulates mammary tumor progression in response to collagen density. Esbona K, Inman D, Saha S, Jeffery J, Schedin P, Wilke L, Keely P. Breast cancer research : BCR. 2016 18:35. (WB; Human)
[Full Text Article]
[PubMed:27000374]
[PMC:PMC4802888]
2
Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation. Tao Peng, R Savanh Chanthaphavong, Sijie Sun, James A Trigilio, Khamsone Phasouk, Lei Jin, Erik D Layton, Alvason Z Li, Colin E Correnti, Willem De van der Schueren, Julio Vazquez, Diana R O'Day, Ian A Glass, David M Knipe, Anna Wald, Lawrence Corey, Jia Zhu. The Journal of experimental medicine. 2017 August;214:2315-2329. [Full Text Article]
[PubMed:28663436]
[PMC:PMC5551564]
3
Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies. Travis K Hughes, Marc H Wadsworth nd, Todd M Gierahn, Tran Do, David Weiss, Priscila R Andrade, Feiyang Ma, Bruno J de Andrade Silva, Shuai Shao, Lam C Tsoi, Jose Ordovas-Montanes, Johann E Gudjonsson, Robert L Modlin, J Christopher Love, Alex K Shalek. Immunity. 2020 October;53:878-894.e7. [Full Text Article]
[PubMed:33053333]
[PMC:PMC7562821]
Related Antibodies: LS-C359381.
☰ Filters
Products
Proteins
(16)
Type
Recombinant
(16)
Target
IL17RA
(16)
Publications
No
(16)
Tag
6His, C-terminus
(1)
Fc
(1)
Fc, C-terminus
(3)
GST, N-terminus
(1)
His
(5)
His, N-Terminal
(1)
His,C-terminus
(2)
His-T7
(1)
Myc-DDK (Flag)
(1)
Species
Human
(11)
Mouse
(2)
Rat
(3)
Source
E. coli
(5)
HEK 293 Cells
(2)
Human Cells
(4)
Mammalian Cells
(4)
Wheat Germ Extract
(1)
Purification
Purified
(5)
Low Endotoxin Level
Low endotoxin level
(9)
Biologically Active
Biologically active
(1)
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
60.6kD
10 µg/$248; 50 µg/$321; 500 µg/$785; 1 mg/$1,021
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
34.1 kDa
100 µg/$926
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
59.7 kDa
100 µg/$926
HEK 293 Cells
Myc-DDK (Flag)
93.2 kDa
20 µg/$1,107
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Mammalian Cells
6His, C-terminus
Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).
10 µg/$248; 50 µg/$321; 500 µg/$761; 1 mg/$1,067
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
34.8 kDa
100 µg/$793; 1 mg/$4,191
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
34.5 kDa
10 µg/$248; 50 µg/$317
E. coli
His, N-Terminal
18kDa
10 µg/$287; 50 µg/$482; 200 µg/$962; 100 µg/$770; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
E. coli
His-T7
29.5 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
60.6 kDa
10 µg/$248; 50 µg/$317
Mammalian Cells
Fc, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
60.6 kDa
50 µg/$356; 10 µg/$259; 1 mg/$1,261; 500 µg/$1,025
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
35 kDa
100 µg/$721
E. coli
His
17.8 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
His
19.3 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
His
30.3 kDa
10 µg/$289; 50 µg/$490; 100 µg/$782; 200 µg/$977; 1 mg/$2,114; 500 µg/$1,640; 5 mg/$3,417; 2 mg/$2,304
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