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IL17RA

interleukin 17 receptor A

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: interleukin 17 receptor A
Family/Subfamily: Interleukin
Synonyms: IL17RA, CANDF5, CD217 antigen, CDw217, CD217, HIL-17R, IL-17RA, IL17R, Interleukin-17 receptor A, IL-17 receptor, IL-17 receptor A, Interleukin 17 receptor, Interleukin 17 receptor A
Target Sequences: NM_014339 NP_055154.3 Q96F46

Publications (3)

1
COX-2 modulates mammary tumor progression in response to collagen density. Esbona K, Inman D, Saha S, Jeffery J, Schedin P, Wilke L, Keely P. Breast cancer research : BCR. 2016 18:35. (WB; Human) [Full Text Article] [PubMed:27000374] [PMC:PMC4802888]
2
Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation. Tao Peng, R Savanh Chanthaphavong, Sijie Sun, James A Trigilio, Khamsone Phasouk, Lei Jin, Erik D Layton, Alvason Z Li, Colin E Correnti, Willem De van der Schueren, Julio Vazquez, Diana R O'Day, Ian A Glass, David M Knipe, Anna Wald, Lawrence Corey, Jia Zhu. The Journal of experimental medicine. 2017 August;214:2315-2329. [Full Text Article] [PubMed:28663436] [PMC:PMC5551564]
3
Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies. Travis K Hughes, Marc H Wadsworth nd, Todd M Gierahn, Tran Do, David Weiss, Priscila R Andrade, Feiyang Ma, Bruno J de Andrade Silva, Shuai Shao, Lam C Tsoi, Jose Ordovas-Montanes, Johann E Gudjonsson, Robert L Modlin, J Christopher Love, Alex K Shalek. Immunity. 2020 October;53:878-894.e7. [Full Text Article] [PubMed:33053333] [PMC:PMC7562821] Related Antibodies: LS-C359381.

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IL17RA (6)
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IL17RA ELISA Kit
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96-Well Microplate
Human
12.35 - 3000 pg/ml
Colorimetric - 450nm (TMB)
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1 Plate/$534
IL17RA ELISA Kit
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96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$699
IL17RA ELISA Kit
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12 x 8-Well Microstrips
Human
32 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
IL17RA ELISA Kit
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96-Well Strip Plate
Human
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
IL17RA ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
IL17RA ELISA Kit
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Sandwich
96-Well Strip Plate
Human
39 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$822
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).