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Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Gene Name: | interleukin 16 |
Family/Subfamily: | Hormone , not assigned-Hormone |
Synonyms: | IL16, IL-16, Interleukin 16, Neuronal interleukin 16, PrIL-16, NIL16, HsT19289, LCF, PRIL16, Pro-interleukin-16, Prointerleukin 16 |
Target Sequences: | NM_004513 NP_004504.3 Q14005 |
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