Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
IL12RB1 / CD212 is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
Gene Name: | interleukin 12 receptor, beta 1 |
Family/Subfamily: | Interleukin |
Synonyms: | IL12RB1, CD212, IL-12R subunit beta-1, IL-12R-beta-1, IL12R, Interleukin-12 receptor, IL-12 receptor subunit beta-1, IL-12R-BETA1, IL-12RB1, CD212 antigen, IL-12 receptor beta component, IL12RB |
Target Sequences: | NM_005535 NP_005526.1 P42701 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.