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IL11
interleukin 11
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.
| Gene Name: | interleukin 11 |
| Family/Subfamily: | Hormone , not assigned-Hormone |
| Synonyms: | IL11, AGIF, Adipogenesis inhibitory factor, IL-11, Interleukin-11, Interleukin 11 |
| Target Sequences: | NM_000641 NP_000632.1 P20809 |
Publications (1)
1
Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer10<sup> Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA12<sup> Department of Immunology, Juntendo University Graduate School of Medicine, Tokyo, Japan14<sup> Department of Pathology, Toho University School of Medicine, Tokyo, Japan16<sup> Host Defense Research Center, Toho University School of Medicine, Tokyo, Japan. hiroyasu.nakano@med.toho-u.a. Takashi Nishina, Yutaka Deguchi, Daisuke Ohshima, Wakami Takeda , Masato Ohtsuka , Shigeyuki Shichino, Satoshi Ueha, Soh Yamazaki, Mika Kawauchi, Eri Nakamura, Chiharu Nishiyama, Yuko Kojima, Satomi Adachi-Akahane, Mizuho Hasegawa, Mizuho Nakayama, Masanobu Oshima, Hideo Yagita, Kazutoshi Shibuya, Tetuo Mikami, Naohiro Inohara, Kouji Matsushima, Norihiro Tada, Hiroyasu Nakano. Nature communications. 2021 Apr;12:2281. [Full Text Article]
[PubMed:33863879]
[PMC:PMC8052408]
Related Antibodies: LS-C408373.
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Sandwich
96-Well Strip Plate
Mouse
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Microplate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Strip Plate
Guinea pig
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Strip Plate
Rat
0.0156 - 1 mg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
Sandwich
96-Well Strip Plate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
12 x 8-Well Microstrips
Human
32 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
Sandwich
96-Well Microplate
Human
1.097 - 266.7 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
Sandwich
96-Well Microplate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
Sandwich
96-Well Microplate
Mouse
0.617 - 150 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
Sandwich
96-Well Strip Plate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$441
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
Sandwich CLIA
96-Well Strip Plate
Rat
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
Development Kit
1000 Wells
Human
32 - 2000 pg/ml
Colorimetric - 405nm (ABTS)
1 Test/$540
Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich CLIA
12 x 8-Well Microstrips
Human
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$822
Sandwich
96-Well Strip Plate
Chicken
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
Sandwich
96-Well Strip Plate
Porcine
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum, Tissue Homogenates, Urine
1 Plate/$744
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