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IL11
interleukin 11
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.
| Gene Name: | interleukin 11 |
| Family/Subfamily: | Hormone , not assigned-Hormone |
| Synonyms: | IL11, AGIF, Adipogenesis inhibitory factor, IL-11, Interleukin-11, Interleukin 11 |
| Target Sequences: | NM_000641 NP_000632.1 P20809 |
Publications (1)
1
Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer10<sup> Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA12<sup> Department of Immunology, Juntendo University Graduate School of Medicine, Tokyo, Japan14<sup> Department of Pathology, Toho University School of Medicine, Tokyo, Japan16<sup> Host Defense Research Center, Toho University School of Medicine, Tokyo, Japan. hiroyasu.nakano@med.toho-u.a. Takashi Nishina, Yutaka Deguchi, Daisuke Ohshima, Wakami Takeda , Masato Ohtsuka , Shigeyuki Shichino, Satoshi Ueha, Soh Yamazaki, Mika Kawauchi, Eri Nakamura, Chiharu Nishiyama, Yuko Kojima, Satomi Adachi-Akahane, Mizuho Hasegawa, Mizuho Nakayama, Masanobu Oshima, Hideo Yagita, Kazutoshi Shibuya, Tetuo Mikami, Naohiro Inohara, Kouji Matsushima, Norihiro Tada, Hiroyasu Nakano. Nature communications. 2021 Apr;12:2281. [Full Text Article]
[PubMed:33863879]
[PMC:PMC8052408]
Related Antibodies: LS-C408373.
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IL11 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
IL11 Rabbit anti-Human Polyclonal (aa22-199) Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
100 µl/$389
IL11 Rabbit anti-Human Polyclonal (aa22-199) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
IL11 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
500 µg/$326
IL11 Rabbit anti-Human Polyclonal (N-Terminal) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µl/$289; 100 µl/$319; 200 µl/$389
IL11 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
IL11 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
IL11 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Func, Neut
Unconjugated
500 µg/$508
IL11 Mouse anti-Human Monoclonal (KT8) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$437
IL11 Rabbit anti-Human Polyclonal (Gly27) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
50 µl/$321; 100 µl/$403
IL11 Mouse anti-Human Monoclonal (3C6) Antibody
Human
ELISA
Unconjugated
100 µg/$423
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
19.3 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$282; 10 µg/$370
Sandwich
96-Well Strip Plate
Mouse
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
293F Cells
His, N-Terminal
24kDa
10 µg/$283; 50 µg/$457; 200 µg/$912; 1 mg/$2,032; 5 mg/$3,193; 2 mg/$2,219
Sandwich
96-Well Microplate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Strip Plate
Guinea pig
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Strip Plate
Rat
0.0156 - 1 mg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
IL11 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IL11 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
50 µg/$305; 100 µg/$357
IL11 Rabbit anti-Human Polyclonal (aa22-199) Antibody
Human
WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
Sandwich
96-Well Strip Plate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
~23 kDa (SDS-PAGE)
5 µg/$296; 25 µg/$478; 1 mg/$3,661
IL11 Mouse anti-Human Monoclonal (aa25-74) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
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