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DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems.
Gene Name: | IKAROS family zinc finger 4 (Eos) |
Synonyms: | IKZF4, KIAA1782, Zinc finger protein Eos, ZNFN1A4, EOS |
Target Sequences: | NM_022465 NP_071910.3 Q9H2S9 |
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