IKZF1 / IKAROS

IKAROS family zinc finger 1 (Ikaros)

IKZF1 / IKAROS is a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

IKZF1 / IKAROS (5)

Publications

No (5)

Tag

6His-AVI, N-terminus (1)

GST (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human IKZF1 / IKAROS Protein (Recombinant 6His-AVI, N-terminus) (Full Length) - LS-G136453

Source:

E. coli

Tag:

6His-AVI, N-terminus

Molecular Weight:

56.8 kDa

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human IKZF1 / IKAROS Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66008

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.3 kDa

Price:

20 µg/$1,107

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Human IKZF1 / IKAROS Protein (Recombinant GST) (Full Length) - LS-G32085

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

79.1 kDa

Price:

2 µg/$439

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Human IKZF1 / IKAROS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76744

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.3 kDa

Price:

20 µg/$215

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IKZF1 / IKAROS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115556

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.3 kDa

Price:

100 µg/$710

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