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IKZF1 / IKAROS
IKAROS family zinc finger 1 (Ikaros)
IKZF1 / IKAROS is a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).
| Gene Name: | IKAROS family zinc finger 1 (Ikaros) |
| Synonyms: | IKZF1, CLL-associated antigen KW-6, HIk-1, Hs.54452, IK1, IKAROS, Ikaros/lyf-1 homolog, LyF-1, PRO0758, DNA-binding protein Ikaros, Ikaros (zinc finger protein), LYF1, ZNFN1A1 |
| Target Sequences: | NM_006060 NP_006051.1 Q13422 |
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