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IKBKG / NEMO / IKK Gamma
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
| Gene Name: | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma |
| Family/Subfamily: | Protein Kinase Non Catalytic , IKAPPAB |
| Synonyms: | IKBKG, AMCBX1, FIP3, Fip3p, IkappaB kinase gamma, IKKgamma, IKK-gamma, NEMO, NF-kappa-B essential modifier, I-kappa-B kinase gamma-subunit, I-kappa-B kinase subunit gamma, IkB kinase gamma subunit, IKKAP1, Incontinentia pigmenti, IP2, IPD2, NF-kappa-B essential modulator, ZC2HC9, FIP-3, IkB kinase subunit gamma, IKKG, IP1, NFkappaB essential modulator |
| Target Sequences: | NM_003639 NP_003630.1 Q9Y6K9 |
Publications (1)
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