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IKBKG / NEMO / IKK Gamma
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
| Gene Name: | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma |
| Family/Subfamily: | Protein Kinase Non Catalytic , IKAPPAB |
| Synonyms: | IKBKG, AMCBX1, FIP3, Fip3p, IkappaB kinase gamma, IKKgamma, IKK-gamma, NEMO, NF-kappa-B essential modifier, I-kappa-B kinase gamma-subunit, I-kappa-B kinase subunit gamma, IkB kinase gamma subunit, IKKAP1, Incontinentia pigmenti, IP2, IPD2, NF-kappa-B essential modulator, ZC2HC9, FIP-3, IkB kinase subunit gamma, IKKG, IP1, NFkappaB essential modulator |
| Target Sequences: | NM_003639 NP_003630.1 Q9Y6K9 |
Publications (1)
1
Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis-like disease and inflammation. Bahram Razani , Michael I Whang , Francis S Kim, Mary C Nakamura, Xiaofei Sun, Rommel Advincula, Jessie A Turnbaugh, Mihir Pendse, Priscilia Tanbun, Philip Achacoso, Peter J Turnbaugh, Barbara A Malynn, Averil Ma. Nature immunology. 2020 April;21:422-433. [Full Text Article]
[PubMed:32205880]
[PMC:PMC7195210]
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IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal (pSer85) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$315
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
IKBKG / NEMO / IKK Gamma Mouse anti-Human Monoclonal (46B844) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$460
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal (320-400 aa) Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
![IKBKG / NEMO / IKK Gamma Antibody - Immunofluorescence of monoclonal antibody to IKBKG on HeLa cell. [antibody concentration 8 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/ikbkg-nemo-ikk-gamma-antibody-clone-4g9-ls-c133550/52073_5108818.jpg)
IKBKG / NEMO / IKK Gamma Mouse anti-Human Monoclonal (4G9) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal (aa51-100) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal (pSer31) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$315
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Bovine, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal (pSer85) Antibody
Human
WB
Unconjugated
50 µg/$305; 100 µg/$357
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal (pSer31) Antibody
Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal (30-110 aa) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal (His81) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$688
Wheat Germ Extract
GST
71.83 kDa
10 µg/$479; 25 µg/$670
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal (pSer31) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal (aa16-65) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IKBKG / NEMO / IKK Gamma Rabbit anti-Human Polyclonal (pSer85) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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