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Infectious Disease
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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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IKBKB / IKK2 / IKK Beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
| Gene Name: | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
| Family/Subfamily: | Protein Kinase , IKAPPAB |
| Synonyms: | IKBKB, Ikk 2, IKK-B, IKK2, IKKbeta, NFKBIKB, I-kappa-B kinase 2, IKKB, I-kappa-B-kinase beta, Ikb kinase-beta, IKK Beta, IKK-beta |
| Target Sequences: | AF080158 AAD08997.1 O14920 |
Publications (2)
1
Regulation of breast cancer induced bone disease by cancer-specific IKKß. Marino S, Bishop RT, Capulli M, Sophocleous A, Logan JG, Mollat P, Mognetti B, Ventura L, Sims AH, Rucci N, Ralston SH, Idris AI. Oncotarget. 2018 March;9:16134-16148. (Human)
[Full Text Article]
[PubMed:29662632]
[PMC:PMC5882323]
Related Antibodies: LS-B1362.
2
MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKß and inducing IKKß-mediated FoxO1 nuclear export and Foxp3 downregulation. Jyun-Ni Chi, Jhih-Yu Yang, Chia-Hsin Hsueh, Ching-Yi Tsai, Huai-Chia Chuang, Tse-Hua Tan. Theranostics. 2022 August;12:5744-5760. [Full Text Article]
[PubMed:35966593]
[PMC:PMC9373822]
Related Antibodies: LS-C157829.
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Products
Antibodies
(213)
Type
Primary
(213)
Target
IKBKB / IKK2 / IKK Beta
(213)
Reactivity
Human
(195)
Mouse
(74)
Rat
(49)
Bovine
(10)
Chimpanzee
(7)
Dog
(5)
Gibbon
(6)
Guinea pig
(6)
Hamster
(1)
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(8)
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(11)
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(7)
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(5)
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(43)
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(110)
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rabbit
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(132)
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(16)
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(1)
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(1)
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monoclonal mc
(23)
polyclonal pc
(190)
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(2)
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(20)
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(16)
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(23)
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(2)
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(2)
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(23)
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(23)
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(20)
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(100)
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(15)
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(8)
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(7)
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(7)
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(7)
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(7)
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(7)
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(7)
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(7)
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(7)
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(7)
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(7)
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(7)
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(7)
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(6)
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(4)
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(4)
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(4)
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(2)
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(2)
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(1)
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(1)
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(1)
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(1)
aa161-210
(1)
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(1)
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(1)
aa398-756
(1)
aa493-739
(1)
aa530-757
(1)
aa587-615
(1)
aa588-604
(1)
aa706-756
(1)
p188
(1)
pSer177/Ser181
(1)
pSer733
(1)
Publications
No
(211)
Yes
(2)
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$515
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (pSer733) Antibody
Human
DB
Unconjugated
400 µl/$393
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (pSer177/Ser181) Antibody
Human
WB
Unconjugated
100 µl/$689
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (pSer697) Antibody
Human
DB
Unconjugated
400 µl/$393
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µl/$917
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (aa161-210) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (aa395-444) Antibody
Human
WB
Unconjugated
100 µl/$424
IKBKB / IKK2 / IKK Beta Chicken anti-Human Polyclonal (aa310-376) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$485
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (pTyr188) Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (pTyr199) Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (aa166-215) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$460
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (aa493-739) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$450
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (pTyr188) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (pTyr199) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (pTyr199) Antibody
Mouse, Bovine, Rat, Pig, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$315
IKBKB / IKK2 / IKK Beta Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (aa398-756) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (130-210 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal (140-220 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IKBKB / IKK2 / IKK Beta Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
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product results
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