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6737 Mowry Ave
Newark, CA 94560
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IHH

Indian hedgehog

Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).

Gene Name: Indian hedgehog
Family/Subfamily: Protease , Cysteine C46
Synonyms: IHH, Indian hedgehog, Indian hedgehog homolog, Indian hedgehog protein, HHG2, BDA1, HHG-2
Target Sequences: BC034757 Q14623 Q14623

Publications (1)

1
Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis. Eoin D O'Sullivan, Katie J Mylonas, Cuiyan Xin, David P Baird, Cyril Carvalho, Marie-Helena Docherty, Ross Campbell, Kylie P Matchett, Scott H Waddell, Alexander D Walker, Kevin M Gallagher, Siyang Jia, Steve Leung, Alexander Laird, Julia Wilflingseder, Michaela Willi, Maximilian Reck, Sarah Finnie, Angela Pisco, Sabrina Gordon-Keylock, Alexander Medvinsky, Luke Boulter, Neil C Henderson, Kristina Kirschner, Tamir Chandra, Bryan R Conway, Jeremy Hughes, Laura Denby, Joseph V Bonventre, David A F. Science translational medicine. 2023 May;15:eabn0736. [Full Text Article] [PubMed:37256934]

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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
IHH (7)
No (7)
His (2)
His, N-Terminal (1)
Myc-DDK (Flag) (2)
Human (5)
293T Cells (1)
E. coli (5)
HEK 293 Cells (1)
Purified (2)
Low endotoxin level (1)
Biologically active (2)
IHH Protein
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Human IHH Protein (Recombinant) (aa29-202) - LS-G5586
E. coli
None
Biologically active
19.8 kDa
5 µg/$282; 100 µg/$1,116; 500 µg/$2,095
IHH Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
Human IHH Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92728
293T Cells
Myc-DDK (Flag)
45.25 kDa
20 µg/$150
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Human IHH Protein (Recombinant His) (aa203-411) - LS-G21686
E. coli
His
26.7 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
IHH Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
IHH Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118138
HEK 293 Cells
Myc-DDK (Flag)
45.25 kDa
100 µg/$494
IHH Protein - Recombinant Hedgehog Homolog, Indian (IHH) by SDS-PAGE
Select
Human IHH Protein (Recombinant His, N-Terminal) (Val45-Ser195) - LS-G133136
E. coli
His, N-Terminal
20.9kDa
10 µg/$279; 50 µg/$432; 200 µg/$862; 100 µg/$690; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
Select
IHH Protein (Recombinant) (Cys28-Gly202) - LS-G27297
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
20 kDa (SDS-PAGE)
50 µg/$364; 10 µg/$278; 1 mg/$1,612
IHH Protein - Recombinant Hedgehog Homolog, Indian By SDS-PAGE
Select
Human IHH Protein (Recombinant His) (aa240-399) - LS-G15183
E. coli
His
19.2 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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