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IGFALS / ALS is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene.
Gene Name: | insulin-like growth factor binding protein, acid labile subunit |
Synonyms: | IGFALS, ALS |
Target Sequences: | NM_001146006 NP_001139478.1 P35858 |
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