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IGF1

insulin-like growth factor 1 (somatomedin C)

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation.

Gene Name: insulin-like growth factor 1 (somatomedin C)
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: IGF1, IGF-IA, IGF-IB, IGFI, IBP1, IGF-I, Insulin-like growth factor 1, Insulin-like growth factor I, Insulin-like growth factor IA, Insulin-like growth factor IB, Mechano growth factor, Somatomedin-C, IGF1A, MGF
Target Sequences: NM_000618 NP_000609.1 P05019

Publications (5)

1
Tumor-associated B-cells induce tumor heterogeneity and therapy resistance. Somasundaram R, Zhang G, Fukunaga-Kalabis M, Perego M, Krepler C, Xu X, Wagner C, Hristova D, Zhang J, Tian T, Wei Z, Liu Q, Garg K, Griss J, Hards R, Maurer M, Hafner C, Mayerhöfer M, Karanikas G, Jalili A, Bauer-Pohl V, Weihsengruber F, Rappersberger K, Koller J, Lang R, Hudgens C, Chen G, Tetzlaff M, Wu L, Frederick DT, Scolyer RA, Long GV, Damle M, Ellingsworth C, Grinman L, Choi H, Gavin BJ, Dunagin M, Raj A, Scholler N, Gross L, Beqiri M, Bennett K, Watson I, Schaider H, et al. Nature communications. 2017 8:607. (WB; Human) [Full Text Article] [PubMed:28928360] Related Antibodies: LS-C7504.
2
Cytokine Mixtures Mimicking Secretomes From Mesenchymal Stem Cells Improve Medication-Related Osteonecrosis of the Jaw in a Rat Model. Ogata K, Matsumura M, Moriyama M, Katagiri W, Hibi H, Nakamura S. JBMR plus. 2017 September;2:69-80. [Full Text Article] [PubMed:30283893] [PMC:PMC6124208] Related Antibodies: LS-C36891.
3
A defined mix of cytokines mimics conditioned medium from cultures of bone marrow-derived mesenchymal stem cells and elicits bone regeneration. Katagiri W, Sakaguchi K, Kawai T, Wakayama Y, Osugi M, Hibi H. Cell proliferation. 2017 June;50: [Full Text Article] [PubMed:28133828] Related Antibodies: LS-C36891.
4
Biomaterial and implant induced ossification: in vitro and in vivo findings. Pekka K Vallittu, Jussi P Posti, Jaakko M Piitulainen, Willy Serlo, Jorma A Määttä, Terhi J Heino, Stefania Pagliari, Stina M Syrjänen, Giancarlo Forte. Journal of tissue engineering and regenerative medicine. 2020 August;14:1157-1168. [Full Text Article] [PubMed:32415757] [PMC:PMC7496445] Related Antibodies: LS-C388624.
5
Multiple protein biomarker assessment for recombinant bovine somatotropin (rbST) abuse in cattle. Ludwig SK, Smits NG, van der Veer G, Bremer MG, Nielen MW. PloS one. 2013 7:e52917. (Flo; Human) [Full Text Article] [PubMed:23300820] [PMC:PMC3531382] Related Antibodies: LS-C392250.
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☰ Filters
Products
Proteins (63)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (8)
Recombinant (53)
IGF1 (63)
Animal-free (1)
No (63)
6His, N-terminus (6)
6His, N-terminus + Mouse IgG Fc, C-terminus (1)
GST (3)
GST, N-terminus (2)
His (3)
His, N-Terminal (2)
His, N-terminus + Fc, C-terminus (1)
His,C-terminus (1)
His-GST (5)
His-T7 (1)
Myc-DDK (Flag) (7)
Bovine (3)
Chicken (1)
Human (37)
Mouse (10)
Pig (4)
Rabbit (1)
Rat (4)
293F Cells (1)
293T Cells (3)
E. coli (42)
HEK 293 Cells (9)
Human (1)
Wheat Germ Extract (2)
Yeast (3)
Purified (16)
Supernatant (1)
Low endotoxin level (25)
Biologically active (20)
Animal-free (1)
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
7.7 kDa (SDS-PAGE)
50 µg/$286; 10 µg/$253; 1 mg/$330
IGF1 Protein - Recombinant Insulin Like Growth Factor 1 By SDS-PAGE
Select
E. coli
GST, N-terminus
28.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
Select
E. coli
None
Biologically active
9.1 kDa
200 µg/$279; 1 mg/$365
Select
E. coli
None
Less than 0.1 ng/µg protein.
7.7 kDa
100 µg/$339; 1000 µg/$556; 500 µg/$429
IGF1 Protein - Recombinant  Insulin Like Growth Factor 1 By SDS-PAGE
Select
E. coli
His-GST
40.0 kDa
10 µg/$226; 50 µg/$249; 100 µg/$271; 200 µg/$287; 1 mg/$572; 500 µg/$382; 5 mg/$1,189; 2 mg/$667
Select
E. coli
His
9.2 kDa
10 µg/$238; 50 µg/$278; 100 µg/$319; 200 µg/$346; 1 mg/$1,012; 500 µg/$677; 5 mg/$1,785; 2 mg/$1,143
Select
HEK 293 Cells
His, N-Terminal
~8 kDa
100 µg/$298
Select
HEK 293 Cells
His, N-Terminal
~8 kDa
200 µl/$283
IGF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
17.03 kDa
100 µg/$494
Select
E. coli
None
Biologically active
9.1 kDa
200 µg/$268; 1 mg/$349
IGF1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 0.5 EU/µg protein (determined by LAL method).
9.1 kDa
50 µg/$255; 10 µg/$235; 1 mg/$404; 500 µg/$346
IGF1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 0.5 EU/µg protein (determined by LAL method).
7.6 kDa
50 µg/$255; 10 µg/$235; 1 mg/$404; 500 µg/$346
IGF1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 0.5 EU/µg protein (determined by LAL method).
7.3 kDa
50 µg/$255; 10 µg/$235; 1 mg/$404; 500 µg/$346
IGF1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
13.2 kDa
1 mg/$1,355; 100 µg/$420; 20 µg/$323
IGF1 Protein - Recombinant Bovine insulin-like growth factor I detected using Goat anti Bovine insulin-like growth factor I as the capture reagent and Goat anti Bovine insulin-like growth factor I:Biotin as the detection reagent followed by Streptavidin:HRP.
Select
Yeast
None
7.6 kDa
5 µg/$390
IGF1 Protein - MCF-7 cell proliferation induced by human IGF-I.
Select
E. coli
None
Biologically active
Less than 0.1 EU/µg protein (determined by LAL method).
The 70 amino acid recombinant protein has a predicted molecular mass of approximately 7.6 kD. The DTT-reduced and non-reduced protein migrate at approximately 11 kD by SDS-PAGE. The N-terminal amino acid is Gly.
25 µg/$276; 100 µg/$322; 1 mg/$436
IGF1 Protein - MCF-7 cell proliferation induced by mouse IGF-I.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 71 amino acid recombinant protein has a predicted molecular mass of approximately 7.8 kD. The DTT-reduced and non-reduced protein migrate at approximately 10 kD and 11 kD respectively by SDS-PAGE. The N-terminal amino acid is Met.
10 µg/$268; 25 µg/$291; 100 µg/$420
IGF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
17.76 kDa
100 µg/$494
IGF1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
15.18 kDa
100 µg/$494
IGF1 Protein
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~8 kDa
100 µg/$372; 1 mg/$481
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
20 µg/$267
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~8 kDa
50 µg/$324; 250 µg/$746; 1 mg/$1,634
IGF1 Protein - Eukaryotic Insulin Like Growth Factor 1 (IGF1) by SDS-PAGE
Select
293F Cells
6His, N-terminus
14kDa
10 µg/$316; 50 µg/$662; 200 µg/$1,242; 100 µg/$1,045; 1 mg/$2,488; 500 µg/$1,989; 5 mg/$4,621; 2 mg/$2,680
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
7.6 kDa
20 µg/$269; 100 µg/$360
Select
E. coli
None
Less than 0.5 EU/µg protein (determined by LAL method).
7.3 kDa
10 µg/$229; 50 µg/$244
Viewing 1-25 of 63 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).