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IGF1

insulin-like growth factor 1 (somatomedin C)

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation.

Gene Name: insulin-like growth factor 1 (somatomedin C)
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: IGF1, IGF-IA, IGF-IB, IGFI, IBP1, IGF-I, Insulin-like growth factor 1, Insulin-like growth factor I, Insulin-like growth factor IA, Insulin-like growth factor IB, Mechano growth factor, Somatomedin-C, IGF1A, MGF
Target Sequences: NM_000618 NP_000609.1 P05019

Publications (5)

1
Tumor-associated B-cells induce tumor heterogeneity and therapy resistance. Somasundaram R, Zhang G, Fukunaga-Kalabis M, Perego M, Krepler C, Xu X, Wagner C, Hristova D, Zhang J, Tian T, Wei Z, Liu Q, Garg K, Griss J, Hards R, Maurer M, Hafner C, Mayerhöfer M, Karanikas G, Jalili A, Bauer-Pohl V, Weihsengruber F, Rappersberger K, Koller J, Lang R, Hudgens C, Chen G, Tetzlaff M, Wu L, Frederick DT, Scolyer RA, Long GV, Damle M, Ellingsworth C, Grinman L, Choi H, Gavin BJ, Dunagin M, Raj A, Scholler N, Gross L, Beqiri M, Bennett K, Watson I, Schaider H, et al. Nature communications. 2017 8:607. (WB; Human) [Full Text Article] [PubMed:28928360] Related Antibodies: LS-C7504.
2
Cytokine Mixtures Mimicking Secretomes From Mesenchymal Stem Cells Improve Medication-Related Osteonecrosis of the Jaw in a Rat Model. Ogata K, Matsumura M, Moriyama M, Katagiri W, Hibi H, Nakamura S. JBMR plus. 2017 September;2:69-80. [Full Text Article] [PubMed:30283893] [PMC:PMC6124208] Related Antibodies: LS-C36891.
3
A defined mix of cytokines mimics conditioned medium from cultures of bone marrow-derived mesenchymal stem cells and elicits bone regeneration. Katagiri W, Sakaguchi K, Kawai T, Wakayama Y, Osugi M, Hibi H. Cell proliferation. 2017 June;50: [Full Text Article] [PubMed:28133828] Related Antibodies: LS-C36891.
4
Biomaterial and implant induced ossification: in vitro and in vivo findings. Pekka K Vallittu, Jussi P Posti, Jaakko M Piitulainen, Willy Serlo, Jorma A Määttä, Terhi J Heino, Stefania Pagliari, Stina M Syrjänen, Giancarlo Forte. Journal of tissue engineering and regenerative medicine. 2020 August;14:1157-1168. [Full Text Article] [PubMed:32415757] [PMC:PMC7496445] Related Antibodies: LS-C388624.
5
Multiple protein biomarker assessment for recombinant bovine somatotropin (rbST) abuse in cattle. Ludwig SK, Smits NG, van der Veer G, Bremer MG, Nielen MW. PloS one. 2013 7:e52917. (Flo; Human) [Full Text Article] [PubMed:23300820] [PMC:PMC3531382] Related Antibodies: LS-C392250.
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Antibodies (186)
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Select
IGF1 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, Neut, WB
Unconjugated
200 µg/$832
IGF1 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
IGF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P, WB
Unconjugated
50 µg/$485
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IGF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, RIA
Unconjugated
50 µl/$717
IGF1 Antibody - IHC-P: IGF-1 antibody testing of human breast cancer tissue
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IGF1 Rabbit anti-Human Polyclonal (aa80-96) Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
100 µg/$575
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IGF1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, ICC, WB
Unconjugated
100 µl/$567
IGF1 Antibody - IGF1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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IGF1 Rabbit anti-Human Polyclonal (aa115-144) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
IGF1 Antibody - Western Blot (non-reducing) of IGF-I / IGF1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IGF1 Goat anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
IGF1 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
IGF1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$610
IGF1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
IGF1 ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
IGF1 ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
IGF1 ELISA Kit
Select
Sandwich
96-Well Microplate
Rabbit
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
IGF1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Canine
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$811
IGF1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
7.7 kDa (SDS-PAGE)
50 µg/$286; 10 µg/$253; 1 mg/$330
IGF1 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
IGF1 ELISA Kit
Select
Sandwich
96-Well Microplate
Bovine
1.23 - 300 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$610
Select
IGF1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$860
IGF1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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IGF1 Goat anti-Human Polyclonal (aa100-109) Antibody
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
Select
IGF1 Mouse anti-Human Monoclonal (SPM406) Antibody
Rabbit, Mouse, Rat, Human
Flo, IF
Unconjugated
20 µg/$371; 100 µg/$574
IGF1 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
2.743 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$426
IGF1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$779
IGF1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.19 - 12 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$610
IGF1 Protein - Recombinant Insulin Like Growth Factor 1 By SDS-PAGE
Select
E. coli
GST, N-terminus
28.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
Viewing 1-25 of 316 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).